Physiology and Management of Massive Transfusion

Aug 14, 2016 by in PHARMACY Comments Off on Physiology and Management of Massive Transfusion

B.  Plasma/fresh frozen plasma contains multiple factors for hemostasis and has increasingly been considered a critical component (see Fig. 31-1). C.  Platelet Administration   1.  Following traumatic injury or significant postoperative bleeding, the critical…

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Neuromuscular Blocking Drugs and Reversal Agents

Aug 14, 2016 by in PHARMACY Comments Off on Neuromuscular Blocking Drugs and Reversal Agents

B.  Depolarizing neuromuscular block (also called phase I block) is often preceded by muscle fasciculation. During partial neuromuscular block, depolarizing block is characterized by (a) decrease in twitch tension, (b) no…

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Physiology of the Newborn

Aug 14, 2016 by in PHARMACY Comments Off on Physiology of the Newborn

a.  To meet the elevated metabolic demand, neonatal cardiac output, relative to body weight, is twice that of the adult. This is achieved with a relatively rapid heart rate (140 beats…

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Basic Principles of Physiology

Aug 14, 2016 by in PHARMACY Comments Off on Basic Principles of Physiology

B.  Body fluids can be divided into intracellular and extracellular fluid, depending on their location relative to the cell membrane (Fig. 1-1).   1.  Interstitial fluid is present in the spaces between cells….

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Diuretics

Aug 14, 2016 by in PHARMACY Comments Off on Diuretics

II.  Carbonic Anhydrase Inhibitors A.  Acetazolamide is the prototype of a class of sulfonamide drugs that bind avidly to the enzyme carbonic anhydrase, producing noncompetitive inhibition of enzyme activity, principally in the…

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Pain Physiology

Aug 14, 2016 by in PHARMACY Comments Off on Pain Physiology

III. Peripheral Nerve Physiology of Pain A.  Nociceptors (pain receptors) are a specialized class of primary afferents that respond to intense, noxious stimuli in skin, muscles, joints, viscera, and vasculature.   1.  Nociceptors are…

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Respiratory Pharmacology

Aug 14, 2016 by in PHARMACY Comments Off on Respiratory Pharmacology

  1.  The mainstay of therapy for bronchospasm, wheezing, and airflow obstruction is β-adrenergic agonists (typically delivered via inhalers or nebulizers).   2.  Short-acting β2 agonists such as albuterol, levalbuterol, metaproterenol, and pirbuterol are…

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Peripherally Acting Analgesics

Aug 14, 2016 by in PHARMACY Comments Off on Peripherally Acting Analgesics

  1.  COX-1 is constitutively expressed and catalyzes the production of prostaglandins that are involved in numerous physiologic functions (maintenance of normal renal function in the kidneys, mucosal protection in the gastrointestinal…

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