Mechanisms of Angina Pectoris

Sep 18, 2016 by in PHARMACY Comments Off on Mechanisms of Angina Pectoris

Figure 1.1 Scheme of cardiac pain pathway. Pain originated from the heart is transmitted to a second neuron in the dorsal horn of the spinal cord, which carries out the…

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Nicorandil

Sep 18, 2016 by in PHARMACY Comments Off on Nicorandil

Figure 6.1 Chemical structure of nicorandil Mechanism of Action Anti-Angina Actions Nicorandil has two distinct anti-angina mechanisms (Fig. 6.2) [1–3]. The nitrate component acts mainly on systemic venous (capacitance) vessels…

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Trimetazidine

Sep 18, 2016 by in PHARMACY Comments Off on Trimetazidine

Study Follow up duration Type of intervention % Patients with angina BARI [1] 1 year CABG, PCI 10 % CABG, 30 % PCI COURAGE [2] 5 years PCI, MT 26…

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Nitrates

Sep 18, 2016 by in PHARMACY Comments Off on Nitrates

Compound Usual dose Onsetof action (min) Durationof action Activation Glycerol Trinitrate (GTN) Sublingual0.3–0.6 mg 2–5 10–30 min Mithocondrial activation Spray 0.4 mg 1–2 sprays as needed 2–5 10–30 min Transdermal…

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Ivabradine

Sep 18, 2016 by in PHARMACY Comments Off on Ivabradine

Figure 7.1 Role of ivabradine in cardiovascular pathology. I f channels, in the sinoatrial node, are responsible for an inwardly direct current. The selective binding of ivabradine to I f…

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Ranolazine

Sep 18, 2016 by in PHARMACY Comments Off on Ranolazine

Figure 9.1 Effect of myocardial ischemia on late Na current (lNa) and activation of the vicious circle of events due to lNa. Ranolazine inhibits Calcium overload and thereby improves myocardial…

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Beta-Blockers

Sep 18, 2016 by in PHARMACY Comments Off on Beta-Blockers

Drug Partial agonist activity Lipid solubility Active metabolites Peripheral vasodilatation I. Non–selective beta–blocker (beta–1 and beta–2) Alprenolol + Moderate Yes  Carteolol + Low Yes (weak)  Nadolol 0 Low No  Oxprenolol…

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An Overview of Treatment and Guidelines: ESC/ACC-AHA/NICE

Sep 18, 2016 by in PHARMACY Comments Off on An Overview of Treatment and Guidelines: ESC/ACC-AHA/NICE

Figure 2.1 Summary of ESC guidelines for stable angina management (Figure adapted from Task Force Members et al. [1]).aData for patients with diabetesbIf intolerance, consider using clopidogrel Treatment of Atherosclerosis…

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