Type Histologic spectrum Association with GCNIS Other anatomical sites Age of presentation Incidence (per 100,000) Originating cell Cytogenetic abnormality Ploidy I Prepubertal-type teratoma Dermoid cysts Possibly epidermoid cysts Prepubertal yolk…
Fig. 3.1 Cycle of genomic imprinting (GI). Upon fertilization, the zygote acquires a haploid set of paternally imprinted chromosomes from the father and a haploid set of maternally imprinted chromosomes…
Germ cell tumors Dysgerminoma Yolk sac tumor Embryonal carcinoma Non-gestational choriocarcinoma Mature teratoma Immature teratoma Mixed germ cell tumor Monodermal teratoma and somatic-type tumors arising from a dermoid cyst Struma…
Positive Negative Germ cell tumors Seminoma Spermatocytic tumor Embryonal carcinomas Yolk sac tumors Choriocarcinoma Teratomas (epithelial elements) Non germ cell tumors GISTs, angiomyolipoma, mastocytosis, thymic carcinomas, lung carcinomas, etc….
Mediastinal germ cell tumor Frequency (% cases) Teratoma 43–75 Seminoma 10–37 Yolk sac tumor 2–12 Embryonal carcinoma 2–8 Choriocarcinoma 2 Mature mediastinal teratomas have been described in patients between 1…
Proportion of population covered by cancer registries included in EUROCARE-5 (%)a Number of germ cell tumor cases registered in 2000–2007 Austria 100 2.610 Belgium (Flanders) 58 1.215 Bulgaria 100…
Fig. 11.1 Fetal type adenocarcinoma of the lung. Branching tubules lined by cylindrical epithelium with prominent vacuolation displaying morular aggregates with cells exhibiting optically clear nuclei 11.3 Stomach Gastric teratomas…
Germinoma Embryonal carcinoma Yolk sac tumor Choriocarcinoma Teratoma Immature Mature With malignant transformation Mixed germ cell Other proposed classification systems separate histologic variants into different therapeutic groups based on their…
Type I GCT Type II GCT Type III GCT Type IV GCT Frequency Rare Uncommon Rare Common Location Testis Ovary Extragonadal Testis Ovary Extragonadal Testis Ovary Preexisting GCT Prepubertal…
Age group Anatomical site Usual histologic type Comments Newborn/infancy Sacrococcygeal (40 %) Ovary mediastinal > abdominal (15–20 % vs. 5 %) Cervicofacial (rare <5 %) Teratoma GCT are the most…
