Free Radicals and Sleep Apnea
Authors Group Oxidative stress markers Changes in oxidative stress markers CPAP results Reference Christou et al. (2003) Human adults Antioxidant capacity, TEAC In severe OSAS, TEAC reduced Not measured [5]…
Strategies for the Treatment of Hereditary Hearing Loss
Gene Protein Other names Common mutations Associated features GJB2 Connexin 26 DFNB1 35delG, M34T, 167delT, V37I, 235delC Rarely skin conditions SLC26A4 (PDS) Pendrin DFNB4 His723Arg, Thr416Pro, Leu236Pro Mondini deformity, euthyroid…
Genes and Hearing Loss: Relationship to Oxidative Stress and Free Radical Formation
Alkan C, Coe BP, Eichler EE (2011) Genome structural variation discovery and genotyping. Nat Rev Genet 12(5):363–376PubMedCentralPubMed Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin IJ, Miller JM, Lomax…
Interventions to Prevent Age-Related Hearing Loss
Fig. 16.1 Conceptual model of and strategy against the development of age-related hearing loss Acknowledgements This work was supported by grants from Ministry of Education, Culture, Sports, Science & Technology,…
Genetics and Age-Related Hearing Loss
© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_14 14. Genetics and Age-Related Hearing Loss Robert D. Frisina1 and D. Robert Frisina1…
Assessment of Interventions to Prevent Drug-Induced Hearing Loss
Antineoplastics Aminoglycosides Loop diuretics Antimalarials Macrolides NSAIDS Carboplatin Amikacin Azosemide Chloroquine Azithromycin Aspirin Cisplatin Dihydrostreptomycin Bumetanide Chloroquine phosphate Erythromycin Etodolac Nedaplatin Gentamicin Ethacrynic acid Hydroxychloroquine Fenoprofen Oxaliplatin Kanamycin Furosemide Quinacrine…
Aminoglycoside-Induced Oxidative Stress: Pathways and Protection
Davis JM, Elfenbein J, Schum R, Bentler RA (1986) Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children. J Speech Hear Disord 51(1):53–62PubMed de…
Hearing Loss After Cisplatin: Oxidative Stress Pathways and Potential for Protection
Fig. 11.1 In vivo, cisplatin (left) is hydrolyzed to the monohydrated cisplatin complex (MHC; middle and right), which is highly reactive when protonated ([MHC]+; middle) When performing kinetic studies of…
Strategies for Evaluating Antioxidant Efficacy in Clinical Trials Assessing Prevention of Noise-Induced Hearing Loss
Population Drug and dose Noise Outcome Attias et al. (1994) 300 normal-hearing (<20 dB HL from 1 to 8 kHz) recruits completing 2 months of basic training; ages 17.7–18.5…
Free Radicals and Oxidative Stress: Basic Concepts and Misconceptions
Fig. 2.1 Redox chemistry of free radicals in vivo. Oxygen (O2) reacts slowly to accept a single electron and produce superoxide (O2 •−) in vivo [1], while two electrons can…
