Basicmedical Key

Fig. 30.1. Lichen simplex chronicus . Acanthosis, hyperkeratosis, and chronic inflammation in the dermis are typical features.   ♦ Hyperkeratosis, parakeratosis, and hypergranulosis may be present   ♦ Surface erosion…

Fig. 29.1. Fibrocystic change. (A) Cystically dilated ducts and (B) apocrine metaplasia are characteristic.   ♦ Type 1 cysts are typically lined by metaplastic apocrine cells and type 2 cysts…

Fig. 43.1. Amyloid deposition in the islets of Langerhans. Mild leukocytic infiltrates   Cystic Fibrosis ♦ Pancreatic involvement with “fibrocystic” appearance in 80–90%   ♦ Hyperviscous mucus precipitates in the…

Fig. 6.1. (A) Staphylococcus aureus in gram-stained smear of purulent exudate, (B) Botryomycotic abscess (H&E). Special Stains ♦ Staphylococci are 0.5–1.0 μm gram-positive spherical to “kidney bean”-shaped cocci with a…

Fig. 2.1. Polymer-based detection system, providing amplification of the signal, with low background and excellent reproducibility.   ♦ The “primary” antibody binds to the test antigen in the tissue section;…

Fig. 32.1. Ovarian serous surface inclusion lined by a flattened serous epithelium. Serous surface inclusions lack associated granulosa cells or luteinized stromal cells.   Follicular Cyst Clinical ♦ Follicular cysts…

Fig. 17.1. Chronic myelogenous leukemia. Peripheral blood smear with increased granulocytes with left shift, including increased basophils. Definition ♦ MPN associated with the BCR/ABL1 gene fusion of marrow stem cells,…

Fig. 16.1. Approach to examination of the spleen. Grossly, normal spleen has small white flecks in a background of purple-red, representing the white and red pulp, respectively The gross presentation…

Markers Tumors Staining pattern Comments/potential pitfalls MDM2/ CDK4 Well-differentiated liposarcoma Dedifferentiated liposarcoma Intimal sarcoma Nuclear 10% of well-dedifferentiated liposarcomas are negative by IHC and may need FISH for MDM2 amplification…

Fig. 19.1. Acute spongiotic dermatitis with spongiotic microvesicles. • In acute spongiotic dermatitis, the epidermis retains its normal “basket-weave” stratum corneum. The epidermis also has pale keratinocytes and spongiosis with…