12 Cancer and the immune system CHAPTER CONTENTS Cancer and carcinogens DNA damage Initiation, promotion and progression Carcinogenic essential oil constituents Defense mechanisms Induction of detoxifying enzymes Antioxidant activity Antimutagenesis…
2 Essential oil composition CHAPTER CONTENTS Essential oils Isolation Composition Chemotypes Contamination Biocides Solvents Phthalates Adulteration Degradation Oxygen Heat Light Other factors Prevention Essential oil chemistry Analytical techniques The structure…
4 Kinetics and dosing CHAPTER CONTENTS Absorption Bioavailability The substance administered The mode and route of administration The recipient Dermal administration The structure of the skin Percutaneous absorption Dermal dosing…
14 Constituent profiles CHAPTER CONTENTS Isomers Constituent profiles A–Z The purpose of these profiles is to provide safety information for essential oil constituents, all of which are referred to in…
11 The reproductive system CHAPTER CONTENTS Reproductive toxicology Xenobiotics in pregnancy and lactation Fertility Female Fertility Estrogenic activity Dopaminergic activity Male Fertility Estrogenic and androgenic activity Other actions Conception Implantation…
9 The digestive system CHAPTER CONTENtS The gastrointestinal tract Dose-related effects Excipients The liver Hepatotoxicity Liver function tests Oxidative stress Visible lesions Fatty degeneration Porphyrin production Glutathione depletion Hepatocellular toxicity…
10 The nervous system CHAPTER CONTENTS Neurotoxicity Structural changes Phytol Functional effects CNS stimulant activity Convulsants Pinocamphone Thujone Camphor Pulegone Eucalyptus oil Fennel oil Turpentine oil Other reported cases Animal…
13 Essential oil profiles CHAPTER CONTENTS Notes Information given in the profiles Regulatory guidelines GRAS EU allergens legislation IFRA guidelines Adjusting safe doses and concentrations The amount applied Combinations of…
