Engineering Miniature Imaging Instruments
Spiral Rotational Galvo MEMS Scanner Location Distal Distal Proximal Distal Fast axis >1 kHz >1 kHz 1–5 kHz >3 kHz Slow axis NA NA <10 Hz <30 Hz Footprint <3 mm <3 mm <1 cm <1 mm Fiber (mode)…
Engineering Aptamers for Biomedical Applications: Part I
Fig. 15.1 The general procedure for systematic evolution of ligands by exponential enrichment (SELEX). Recreated with kind permission of Elsevier Ltd [100] 15.2.2 Improved SELEX Along with the continuous development, a…
Opportunities for New Photodynamic Molecular Beacon Designs
Fig. 27.1 a Molecular structure of a pyrene-functionalized cationic oligopeptide. b Binding of the beacon to double-stranded DNA. c Schematic working mechanism (Recreated with kind permission from American Chemical Society; J….
Engineering of Mesoporous Silica Nanoparticles for In Vivo Cancer Imaging and Therapy
Fig. 23.1 a Fluorescence imaging of MSN-NH2-FITC (left) and MSN-ICG (middle) in anesthetized rats before and 90 min after i.v. injection. Scanning time was all set to be 30 s. The fluorescence image…
Engineering AApeptides for Translational Medicine
Fig. 35.1 Examples of unnatural peptidomimetics As they are not based on regular peptide backbones, they are often much more stable against proteolysis and have improved bioavailability compared to peptide counterparts…
Engineering Small Animal Conformal Radiotherapy Systems
Fig. 31.1 State-of-the-art medical linear accelerator (a) and a patient dose distribution generated by a treatment technique called RapidArc (b). Small animal conformal radiotherapy system at Stanford University based on a…
Engineered Affibodies in Translational Medicine
Fig. 12.1 Affibody-binding proteins: library and target binding. Illustration of the three-helix bundle affibody protein scaffold Z in band representation (green), with the 13 positions randomized during affibody protein library constructions…
Engineering Carbon Nanomaterials for Stem Cell-Based Tissue Engineering
Engineered nanostructure Stem cell Differentiated cell Proposed mechanism Reference LBL-assembled SWCNT/PEI polyelectrolyte composite mNSCs Neurons, oligodendrocytes, astrocytes Chemical structure better suitable as neural electrode [36] LBL-assembled SWCNT/laminin composite mNSCs Neurons…
Tissue Engineering Applications for Peripheral Nerve Repair
Fig. 5.1 The types of neural scaffolds are shown on the left-hand side of the diagram, and the components of tissue-engineered nerve grafts are shown on the right-hand side. Adapted with…
Alternative Protein Scaffolds for Molecular Imaging and Therapy
Name Amino acids Topology Typical paratope Stability (T m , °C) Parental Binders Knottin 20–50 Knotted 3-disulfide core Loop 1 ~100 N.d. Affibody 58 Triple α-helical bundle 13 amino acids…
