Pleomorphic Carcinoma Key Facts Terminology Malignant epithelial neoplasm composed of spindle and multinucleated giant cells in different proportions Etiology/Pathogenesis PC may represent a genetically distinct type of malignancy separate from…
Lymphoepithelioma-like Carcinoma Key Facts Terminology Lymphoepithelioma-like carcinoma (LELC) Malignant epithelial neoplasm with prominent inflammatory component Etiology/Pathogenesis Appears not to be related to tobacco smoke Closely associated with Epstein-Barr virus (EBV)…
Poorly Differentiated Squamous Carcinoma, Small Cell Variant Key Facts Clinical Issues Cough History of cigarette smoking Treatment by surgery, chemotherapy, or radiation depends on stage and grade at presentation Image…
Spindle Cell (Sarcomatoid) Carcinoma Key Facts Terminology Carcinoma with pseudosarcomatous component, pseudosarcomatous carcinoma, spindle cell carcinoma Clinical Issues Cough Chest pain Hemoptysis Macroscopic Features Central or peripheral tumors 2 to…
Squamous Cell Carcinoma Key Facts Terminology Malignant epithelial neoplasm with squamous (epidermoid) differentiation Macroscopic Features Central or peripheral tumors White or light brown in color with homogeneous cut surface; cut…
Adenocarcinoma Key Facts Terminology Malignant epithelial neoplasm with glandular differentiation Etiology/Pathogenesis Close association with tobacco smoking Clinical Issues Cough Weight loss Chest pain Difficulty breathing Macroscopic Features Peripheral or central…
Mucinous (“Colloid”) Carcinoma Key Facts Terminology Mucinous cystadenoma, mucinous cystic tumor, multilocular cystic carcinoma, mucinous cystic tumor of borderline malignancy Macroscopic Features Well-defined tumor mass with mucoid consistency, solid &/or…
Endometrioid-like Carcinoma Key Facts Terminology Malignant epithelial neoplasms with features mimicking secretory endometrium Clinical Issues Symptoms Cough Dyspnea Hemoptysis Chest pain Prognosis Depends on clinical and pathological stage Treatment options…
Signet Ring Cell Carcinoma Key Facts Terminology Synonym: Adenocarcinoma with signet ring cells Definition Non-small cell carcinoma with signet ring cells similar to those described in gastrointestinal tract Clinical Issues…
Bronchioloalveolar Cell Carcinoma Key Facts Terminology Bronchioloalveolar cell carcinoma (BAC) Adenocarcinoma with BAC pattern and no evidence of stromal, vascular, or pleural invasion Essentially, current definition is that of in…
