Unicentric Hyaline Vascular Variant Castleman Disease Pei Lin, MD Key Facts Clinical Issues Young adults Lymphadenopathy, localized Excision is usually curative Microscopic Pathology Large follicles with regressed (involuted) germinal centers…
Kikuchi-Fujimoto Disease Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Self-limited clinical course in most patients Might represent phenotype of diverse disease entities Prognosis is different according to underlying…
Kimura Disease C. Cameron Yin, MD, PhD Key Facts Terminology Chronic inflammatory disease that affects subcutaneous tissue and regional lymph nodes Etiology/Pathogenesis Unknown; infectious cause suspected Clinical Issues Mainly in…
Sarcoid Lymphadenopathy Sa A. Wang, MD Key Facts Terminology Multisystemic chronic granulomatous disease Etiology/Pathogenesis Unknown Clinical Issues Multisystem involvement Therapy may not be required if asymptomatic Prognosis depends on involvement…
Protocol for Examination of Hodgkin Lymphoma Specimens L. Jeffrey Medeiros, MD Hodgkin Lymphoma: Biopsy, Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Lymph node(s) ____…
Rosai-Dorfman Disease Faisal Alseraye, MD L. Jeffrey Medeiros, MD Key Facts Terminology Rosai-Dorfman disease (RDD) and sinus histiocytosis with massive lymphadenopathy are equivalent terms Etiology/Pathogenesis Unknown; histologic features are suggestive…
Progressive Transformation of Germinal Centers Pei Lin, MD Key Facts Terminology Progressive transformation of germinal centers (PTGC) Clinical Issues Young adults most commonly affected Asymptomatic localized lymphadenopathy in most patients…
Human Immunodeficiency Virus Lymphadenitis Tariq Muzzafar, MBBS Key Facts Terminology Human immunodeficiency virus (HIV) Lymphadenitis caused by HIV infection Clinical Issues History of high-risk exposure should be sought Microscopic Pathology…
Inflammatory Pseudotumor Francisco Vega, MD, PhD Key Facts Terminology Inflammatory reaction with multifactorial pathogenesis Infectious etiologies account for subset of cases Clinical Issues Young adults with fever and constitutional symptoms…
Coccidioides Lymphadenitis Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis 2 species: C. immitis prevalent in California, USA; C. posadasii in other regions Clinical Issues May be seen in nonendemic areas Travel…
