Basicmedical Key

Nodular Sclerosis Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology Nodular sclerosis is type of CHL composed of lacunar-type HRS cells and inflammatory cells forming nodules surrounded by…

Myeloid/Monocytic Sarcoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Myeloid/monocytic sarcoma (MS) is tumor mass Can develop de novo (27%), concurrently with, or after diagnosis of AML Can…

Extranodal Marginal Zone B-cell Lymphoma (MALT Lymphoma) Pei Lin, MD Key Facts Etiology/Pathogenesis Infectious agents are implicated in pathogenesis of MALT lymphomas at specific sites Helicobacter pylori: Stomach Campylobacter jejuni:…

Blastic Plasmacytoid Dendritic Cell Neoplasm Wesley O. Greaves, MD L. Jeffrey Medeiros, MD Key Facts Clinical Issues Median age: ˜ 65 years Wide age range: 8-96 years Male to female…

Metastatic Kaposi Sarcoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Etiology/Pathogenesis HHV8 infection plays critical role in most cases Interacts with other factors Clinical Issues Multiple presentations of KS Sporadic…

Immunomodulating Agent-associated Lymphoproliferative Disorders Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis Risk factors for IA-LPDs Type of immunosuppressive drug Duration of drug therapy Underlying disease type and disease activity Patient genetic…

Sezary Syndrome Sa A. Wang, MD Key Facts Terminology Sézary syndrome (SS) is defined by triad of Pruritic erythroderma High number of Sézary cells in blood (> 1,000/µL ) Lymphadenopathy,…

Post-transplant Lymphoproliferative Disorder, Monomorphic Pei Lin, MD L. Jeffrey Medeiros, MD Key Facts Terminology Monomorphic PTLDs fulfill criteria for lymphomas as observed in immunocompetent patients Etiology/Pathogenesis Epstein-Barr virus (EBV) infection…

Plasmablastic Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Diffuse neoplasm with immunoblastic or plasmablastic features and plasma cell immunophenotype Aggressive clinical course Poor prognosis Etiology/Pathogenesis Associated with immunodeficiency HIV…

Follicular Dendritic Cell Sarcoma Sa A. Wang, MD Key Facts Terminology Neoplastic proliferation of follicular dendritic cells Clinical Issues Presents as slow-growing, painless mass Lymph nodes Extranodal sites; Waldeyer ring…