Histoplasmosis
Most common endemic mycosis in United States • Liver involvement is almost always part of disseminated infection Patients often immunocompromised Liver is involved in up to 90% of cases of disseminated…
Serous Cystadenoma
Clear to pale cytoplasm with sharp cell border Small, round to oval, uniform nuclei Periodic acid-Schiff without diastase has granular cytoplasmic staining • Exuberant rich capillary network immediately adjacent to epithelium…
Drug-Related Steatohepatitis/Phospholipidosis
Amiodarone Methotrexate Antiretroviral drugs Nifedipine Clinical Issues • Symptoms may present after months to years of therapy Patients may be asymptomatic despite liver injury • Due to long half-life of amiodarone, may…
Porphyrin Metabolism Disorders
Porphyria cutanea tarda (PCT) and erythropoietic protoporphyria (EP) associated with hepatic pathology • Terms “hepatic” or “erythropoietic” porphyria based on site of heme precursor accumulation Etiology/Pathogenesis • Genetic: Defect in 1 of…
Hepatectomy Specimen Handling
Tumors – Goals of evaluation are to assess margins and stage tumor Medical liver disease – Goal of evaluation is to determine or confirm cause of liver disease &/or liver failure MACROSCOPIC…
Alcoholic Liver Disease
Wide spectrum of disease ranging from subclinical to end-stage liver disease ∼ 20-40% of chronic alcoholics who undergo biopsy have histologic evidence of alcoholic liver disease (ALD) Clinical Issues • Very…
Antibody-Mediated Rejection
Preformed antibodies Donor-specific antibodies (DSA) developed after transplantation Microscopic • Hyperacute antibody-mediated rejection (AMR) Fibrin thrombi in portal and central veins and sinusoids Neutrophilic &/or fibrinoid arteritis Patchy or massive hemorrhagic…
Mucinous Cystic Neoplasm
Range: 14-95 years • Predominantly female F:M = 20:1 Macroscopic • 90% of mucinous cystic neoplasms arise in body or tail of pancreas • Usually solitary and large Mean: 7-10 cm • Usually multiloculated…
Acinar Cell Carcinoma
Minority of patients have associated lipase hypersecretion paraneoplastic syndrome Macroscopic • Solid, well-circumscribed, fleshy mass • Average 10 cm in diameter (range: 2-30 cm) Microscopic • Densely cellular with multiple architectural patterns, most…
Hereditary Hemochromatosis
2 most common mutations (C282Y and H63D) account for vast majority of cases • Non- HFE- associated hereditary hemochromatosis occurs less commonly (5-10% of phenotypic cases) • Specific mechanism leading to iron…
