Basicmedical Key

Nipple Adenoma Key Facts Terminology Benign proliferative lesion arising in major ducts of nipple Clinical Issues Patients present with nipple discharge (bloody or clear) &/or ill-defined indurated mass Skin changes…

Tubulolobular Carcinoma Key Facts Terminology Tubulolobular carcinoma (TLC) Not a synonym for “carcinomas with ductal and lobular features” Etiology/Pathogenesis Low-grade invasive carcinoma with tubule formation and single cell lobular pattern…

Medullary Carcinoma Key Facts Terminology Medullary carcinoma (MC) Rare subtype of invasive breast cancer with characteristic histologic features Etiology/Pathogenesis Many MCs downregulate BRCA1 either by promoter methylation (2/3) or mutation…

Columnar Cell Change with or without Flat Epithelial Atypia Key Facts Terminology Columnar cell change (CCC) Flat epithelial atypia (FEA) Encountered with increasing frequency in breast biopsies performed for mammographic…

Core Needle Biopsies Core needle biopsies for calcifications are radiographed to document that the targeted lesion has been sampled . The cores with calcifications may be separately submitted for more…

Encapsulated Papillary Carcinoma Key Facts Terminology Papillary carcinoma present within single well-circumscribed cystic space Synonyms: Encysted papillary carcinoma, intracystic carcinoma Clinical Issues 0.5-2% of breast cancers in women Most common…

DNA Analysis Labeled DNA from a tumor is hybridized to either metaphase chromosomes (CGH) or a DNA microarray (array-CGH). Deletions or duplications of DNA are detected by comparison with reference…

Syringomatous Adenoma of the Nipple Key Facts Terminology Benign neoplasm morphologically similar to dermal syringoma Clinical Issues Presents as palpable, solitary, firm dermal mass in subareolar or nipple region Management…