Invasive Ductal Carcinoma (Adenocarcinomas of No Special Type) Key Facts Terminology Invasive ductal carcinoma includes carcinomas not classified as a special histologic type Synonymous with “no special type” or “not…
Sclerosing Adenosis Key Facts Clinical Issues Can present as a lesion on mammography, as a palpable mass, or as an incidental finding Classified as proliferative disease without atypia 1.5-2x increased…
Molecular Factor Index Molecular Factors Discussed Molecular Factor Chromosomal Location Alternative Names/Terms Chapters β-actin Expression Profiling, Oncotype DX Assay 10p12, loss of 10p12 Phyllodes Tumor 10q, loss of 10q Epidemiology:…
Locally Recurrent Carcinoma Key Facts Terminology Subsequent carcinoma in breast (after breast-conserving therapy) or in chest wall (after mastectomy) following prior diagnosis of breast carcinoma True recurrent carcinoma is due…
Size and Multiple Foci Size is a very important prognostic factor and refers to the greatest linear dimension of an invasive carcinoma . Surrounding carcinoma in situ is not included…
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names Chapters β-catenin beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway B-catenin, CLONE 14,…
Invasive Apocrine Carcinoma Key Facts Terminology Invasive apocrine carcinoma (IAC) Term is reserved for cases in which nearly all tumor cells show prominent apocrine features Etiology/Pathogenesis Molecular studies indicate that…
Inflammatory Carcinoma Key Facts Terminology Inflammatory breast carcinoma (IBC) Characteristic clinical presentation of edema and erythema of > 1/3 of breast skin Clinical Issues 1-5% of all breast cancer cases…
Basal-like Carcinomas Key Facts Terminology Triple negative breast cancer (TNBC) Basal-like carcinoma (BLC) Lack of hormone receptor expression Low expression of HER2 High expression of basal cytokeratins 5, 14, &…
Secretory Carcinoma Key Facts Clinical Issues Very rare type of invasive breast carcinoma (< 0.2% of breast carcinomas) Occurs over wide age range: < 5 years to > 80 years…
