Basicmedical Key

Metaplastic Carcinoma Key Facts Terminology Metaplastic breast carcinoma (MBC) includes a diverse group of tumors consisting entirely, or in part, of components that do not have the histologic appearance of…

Papilloma, Large Duct and Small Duct Key Facts Terminology Large duct papilloma (LDP) Usually centrally located; often solitary Originates in lactiferous sinus or large mammary ducts Small duct papilloma (SDP)…

Fibromatosis Key Facts Terminology Neoplastic proliferation of fibroblasts that is locally infiltrative but which does not metastasize Etiology/Pathogenesis Some cases are associated with familial adenomatous polyposis (including Gardner and Turcot…

Lymphoma Key Facts Terminology Malignancy consisting of clonal population of lymphocytes involving breast Primary breast lymphoma: Restricted to breast parenchyma and axillary nodes when initially diagnosed Secondary breast lymphoma: Breast…

Invasive Lobular Carcinoma Key Facts Terminology Invasive lobular carcinomas are characterized by loss of normal cell adhesion and actin cytoskeleton regulation Responsible for specific morphologic appearance, diffuse pattern of infiltration…

HER2 Positive Carcinoma Key Facts Clinical Issues 15-20% of breast carcinomas overexpress HER2 All newly diagnosed invasive breast cancers should be evaluated for HER2 IHC, FISH, and CISH methods have…

Hormone Receptors (ER/PR) Estrogen receptor binds with its ligand estrogen and is transported to the nucleus of the cell where it acts as a transcription factor, regulating the expression of…

Mucinous (Colloid) Carcinoma Key Facts Terminology Mucinous carcinoma (MC) Special histologic type of invasive carcinoma with distinctive features Characterized by abundant extracellular pools of stromal mucin product Clinical Issues Uncommon;…

Neoadjuvant Therapy This MR study shows a large enhancing mass with tethering to the chest wall . A core needle biopsy confirmed a poorly differentiated carcinoma that was negative for…

Myofibroblastoma Key Facts Terminology Myofibroblastoma (MFB) Benign spindle cell mammary tumor, thought to be derived from mammary stromal myofibroblasts Clinical Issues Uncommon mammary neoplasm Typically seen in older patient population…