Superficial Angiomyxoma
Khin Thway, BSc, MBBS, FRCPath
Key Facts
Terminology
Benign, cutaneous myxoid lesion, associated in some cases with Carney complex
Clinical Issues
Trunk, head and neck, lower extremities, and genital area
Microscopic Pathology
Lobular and sparsely cellular
Spindle and stellate cells in myxoid stroma
Minimal to mild atypia
Sparse inflammatory infiltrate ° Neutrophils
Vasculature may be prominent
Admixed epithelial structures in some cases
Ancillary Tests
CD34 expression
Occasional actin-sm expression
 In this superficial angiomyxoma, the dermis shows an illdefined lesion with prominent myxoid stroma, Lesions can also appear circumscribed. |
 Superficial angiomyxoma has a multilobulated appearance  at low power and shows patternless distributions of spindle and stellate cells. |
TERMINOLOGY
Synonyms
Cutaneous myxoma
Definitions
Benign, cutaneous myxoid lesion, associated in some cases with Carney complex
CLINICAL ISSUES
Epidemiology
Age
Adults (mean: 3rd-5th decades)
Rarely congenital
Gender
Slight male preponderance
Site
Most common on trunk, head and neck, and lower extremities
Smaller proportion occur in genital area
Predilection for ear, eyelid, and nipple in Carney complex
Rarely in oral cavity
