Squamoid “Eccrine” Ductal Carcinoma
David Cassarino, MD, PhD
Key Facts
Terminology
Squamoid “eccrine” ductal carcinoma (SEDC)
Rare carcinoma with ductal and squamous features
Clinical Issues
Aggressive local recurrences, but no metastases
Microscopic Pathology
Deeply infiltrative-appearing lobules, nests, and cords of cells
Mixed population of smaller basaloid adnexal cells and larger squamoid cells
Both cell types can surround ductal lumina
Evidence of follicular differentiation can be seen
Suggests that these may represent squamoid variants of microcystic adnexal carcinoma
Top Differential Diagnoses
Squamous cell carcinoma (SCC)
Microcystic adnexal carcinoma (MAC)
 Squamoid eccrine ductal carcinoma shows a proliferation of both enlarged, squamoid cells forming islands  and smaller, more cord-like collections of basaloid cells  . |
 High magnification of a predominantly squamoid area shows collections of large cells with abundant eosinophilic cytoplasm surrounding keratinizing cystic spaces  and small ductal lumina  . |
TERMINOLOGY
Abbreviations
Squamoid “eccrine” ductal carcinoma (SEDC)
Synonyms
Ductal eccrine carcinoma with squamous differentiation
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