Spindle Cell Hemangioma
Steven D. Billings, MD
Key Facts
Terminology
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Formerly called spindle cell hemangioendothelioma
Clinical Issues
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Subcutaneous mass
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Usually acral location
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Sometimes multifocal
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Associated with Mafucci syndrome in some cases
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Local recurrence in 50-60%
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No metastatic potential
Microscopic Pathology
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Dilated vessels often with focal thrombi
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Solid spindled cell areas
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Vacuolated endothelial cells, so-called “blister cells”
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Negative for HHV8 latent nuclear antigen
Top Differential Diagnoses
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Kaposi sarcoma
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Kaposiform hemangioendothelioma
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Epithelioid hemangioendothelioma
Hematoxylin & eosin shows a noncircumscribed lesion in the dermis and subcutis composed of an admixture of thin-walled dilated blood vessels and sheets of spindle cells. |
Hematoxylin & eosin shows straight/curved fascicles of uniform spindle cells  with irregularly shaped vascular spaces  and small areas of hemorrhage. |
TERMINOLOGY
Synonyms
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Formerly called spindle cell hemangioendothelioma
Definitions
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Benign vascular tumor characterized by cavernous and spindled areas
CLINICAL ISSUES
Epidemiology
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Age
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Young adults
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Site
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Distal extremities
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Acral location most common
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