Silicone Reaction

Silicone Reaction

Cyril Fisher, MD, DSc, FRCPath

Hematoxylin & eosin shows fibrous reaction around a breast implant. There are clusters of univacuolated or multivacuolated cells, some containing refractile material image.

Hematoxylin & eosin shows a multinucleated giant cell and lymphocytic reaction around variable-sized cystic spaces in the fibrous tissue.



  • Silicone granuloma


  • Tissue reaction to silicone (dimethylpolysiloxane) implant, liquid silicone, or silicone gel



  • Leakage from prosthetic implant in breast

    • Spontaneous

    • Following trauma, including compression mammography

  • Cosmetic injection

    • Face

      • Nose, lips

    • Earlobes

    • Abdominal wall

    • Genitalia

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Silicone Reaction

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