Progressive Lymphangioma
David Cassarino, MD, PhD
Key Facts
Terminology
Benign, localized proliferation of lymphatic vessels
Also known as
Acquired progressive lymphangioma and benign lymphangioendothelioma
Clinical Issues
Usually presents on lower extremities, but may occur anywhere
Prognosis excellent; local recurrences rare
Microscopic Pathology
Dermal and subcutaneous proliferation of dilated vascular channels
Spaces are often widely dilated superficially, but become narrower with deep extension
Endothelial-lined papillary projections with mild fibrosis may be present
Endothelial cells may show mild hyperchromasia, but no significant atypia
 Low-magnification histologic examination of a progressive lymphangioma shows widely dilated lymphatic spaces in the superficial dermis. |
 High-power examination shows irregular contours of lymphatic spaces and small, bland-appearing lining endothelial cells  . |
TERMINOLOGY
Synonyms
Acquired progressive lymphangioma
Benign lymphangioendothelioma
Definitions
Benign, localized proliferation of lymphatic vessels
ETIOLOGY/PATHOGENESIS
Unknown
May be related to trauma in some cases
CLINICAL ISSUES
Epidemiology
Age
Middle-aged or older adults
Gender
No predilection
Site
Usually presents on lower extremities, but may occur anywhere
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