Ossifying Fibromyxoid Tumor



Ossifying Fibromyxoid Tumor


Cyril Fisher, MD, DSc, FRCPath









Hematoxylin & eosin shows an ossifying fibromyxoid tumor with variable cellularity and a rim of mature bone image with septal extensions image into the tumor mass.






Specimen radiograph shows focal ossification image in the capsule of an ossifying fibromyxoid tumor.


TERMINOLOGY


Abbreviations



  • Ossifying fibromyxoid tumor (OFMT)


Synonyms



  • Ossifying fibromyxoid tumor of soft parts


Definitions



  • Encapsulated tumor of small polygonal cells in fibromyxoid stroma with metaplastic ossification


  • Majority benign; rare atypical or malignant variants


ETIOLOGY/PATHOGENESIS


Differentiation



  • Various lineages suggested



    • Neural (Schwann cell), chondroid, myoepithelial


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare


  • Age



    • 2nd-8th decades



      • Mean 50 years, rare in childhood


  • Gender



    • M:F = 2:1


Site



  • Mostly subcutaneous



    • Extremities, head and neck



      • Also trunk, retroperitoneum, mediastinum


Presentation



  • Painless mass


Treatment



  • Surgical approaches



    • Local excision

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Ossifying Fibromyxoid Tumor
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