of Contents

Table of Contents


Cover image


Title page


Copyright


Dedication


Contributors


Reviewers


Preface


Organization


Features


Ancillaries


Acknowledgments


Unit I: Pathophysiologic Processes


Chapter 1. Introduction to Pathophysiology


Key Questions


Framework for Pathophysiology


Concepts of Normality in Health and Disease


Patterns of Disease in Populations


Summary


References


Chapter 2. Homeostasis and Adaptive Responses to Stressors


Key Questions


Homeostasis and Allostasis


Stress as a Concept


Neurohormonal Mediators of Stress and Adaptation


Adaptation, Coping, and Illness


Summary


References


Unit II: Cellular Function


Chapter 3. Cell Structure and Function


Key Questions


Plasma Membrane


Organization of Cellular Compartments


Cellular Metabolism


Functions of the Plasma Membrane


Intercellular Communication and Growth


Summary


References


Chapter 4. Cell Injury, Aging, and Death


Key Questions


Reversible Cell Injury


Cellular Adaptation


Irreversible Cell Injury


Etiology of Cellular Injury


Cellular Aging


Somatic Death


Summary


References


Chapter 5. Genome Structure, Regulation, and Tissue Differentiation


Key Questions


Molecular Genetics


Regulation of the Genome


Differentiation of Tissues


Summary


References


Chapter 6. Genetic and Developmental Disorders


Key Questions


Principles of Inheritance


Genetic Disorders


Chromosomal Abnormalities


Mendelian Single-Gene Disorders


Nonmendelian Single-Gene Disorders


Polygenic and Multifactorial Disorders


Environmentally Induced Congenital Disorders


Diagnosis, Counseling, and Gene Therapy


Summary


References


Chapter 7. Neoplasia


Key Questions


Benign Versus Malignant Growth


Epidemiology and Cancer Risk Factors


Genetic Mechanisms of Cancer


Multistep Nature of Carcinogenesis


Metastasis


Effects of Cancer on the Body


Cancer Therapy


Summary


References


Unit III: Defense


Chapter 8. Infectious Processes


Key Questions


Epidemiologic Concepts


Host-Microbe Relationship


Types of Pathogenic Organisms


Summary


References


Chapter 9. Inflammation and Immunity


Key Questions


Components of the Immune System


Epithelial Barriers


Mononuclear Phagocyte System


Lymphoid System


Leukocytes


Chemical Mediators Of Immune Function


Innate Defenses and Inflammation


Inflammation


Healing


Inflammatory Exudates


Systemic Manifestations of Inflammation


Specific Adaptive Immunity


Major Histocompatibility Complex


Antigen Presentation by MHC


Mechanisms of Cell-Mediated Immunity


Mechanisms of Humoral Immunity


Passive and Active Immunity


Integrated Function and Regulation of the Immune System


Integrated Response To New Antigen


Regulation of Immune Function


Summary


References


Chapter 10. Alterations in Immune Function


Key Questions


Excessive Immune Responses


Autoimmunity


Hypersensitivity


Deficient Immune Responses


Primary Immunodeficiency Disorders


Secondary Immunodeficiency Disorders


Summary


References


Chapter 11. Malignant Disorders of White Blood Cells


Key Questions


Classification of Hematologic Neoplasms


Etiology of Myeloid and Lymphoid Neoplasms


General Principles of Management


Myeloid Neoplasms


Lymphoid Neoplasms


Summary


References


Chapter 12. HIV Disease and AIDS


Key Questions


Epidemiology


Etiology


Pathogenesis


Diagnostic Testing


Monitoring the Progression of HIV


Clinical Manifestations


Treatment


Summary


References


Unit IV: Oxygen Transport, Blood Coagulation, Blood Flow, and Blood Pressure


Chapter 13. Alterations in Oxygen Transport


Key Questions


Composition of Blood


Structure and Function of Red Blood Cells


Gas Transport and Acid-Base Balance


Anemia


Anemia Related to Decreased Red Cell Production


Anemia Related to Inherited Disorders of the Red Cell


Anemia Related to Extrinsic Red Cell Destruction or Loss


Transfusion Therapy


Polycythemia


Summary


References


Chapter 14. Alterations in Hemostasis and Blood Coagulation


KEY QUESTIONS


The Process of Hemostasis


Evaluation of Hemostasis and Coagulation


Vascular and Platelet Disorders


Coagulation Disorders


Summary


References


Chapter 15. Alterations in Blood Flow


Key Questions


Organization of the Circulatory and Lymphatic Systems


Principles of Flow


Control of Flow


General Mechanisms That Cause Altered Flow


Alterations in Arterial Flow


Alterations In Venous Flow


Alterations In Lymphatic Flow


Summary


References


Chapter 16. Alterations in Blood Pressure


Key Questions


Arterial Blood Pressure


Mechanisms of Blood Pressure Regulation


Hypertension


Low Blood Pressure


Summary


References


Unit V: Cardiac Function


Chapter 17. Cardiac Function


Key Questions


Cardiovascular Anatomy


Cardiac Cycle


Coronary Circulation


Cardiac Myocytes


Molecular Basis of Contraction


Cardiac Energy Metabolism


Cardiac Electrophysiology


Electrocardiography


Determinants of Cardiac Output


Endocrine Function of the Heart


Tests of Cardiac Function


Summary


References


Chapter 18. Alterations in Cardiac Function


Key Questions


Coronary Heart Disease


Endocardial and Valvular Diseases


Myocardial Diseases


Pericardial Diseases


Congenital Heart Diseases


Summary


References


Chapter 19. Heart Failure and Dysrhythmias: Common Sequelae of Cardiac Diseases


Key Questions


Heart Failure


Cardiac Dysrhythmias


Summary

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Sep 3, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on of Contents
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