Table of Contents
Unit I: Pathophysiologic Processes
Chapter 1. Introduction to Pathophysiology
Concepts of Normality in Health and Disease
Patterns of Disease in Populations
Chapter 2. Homeostasis and Adaptive Responses to Stressors
Neurohormonal Mediators of Stress and Adaptation
Adaptation, Coping, and Illness
Chapter 3. Cell Structure and Function
Organization of Cellular Compartments
Functions of the Plasma Membrane
Intercellular Communication and Growth
Chapter 4. Cell Injury, Aging, and Death
Chapter 5. Genome Structure, Regulation, and Tissue Differentiation
Chapter 6. Genetic and Developmental Disorders
Mendelian Single-Gene Disorders
Nonmendelian Single-Gene Disorders
Polygenic and Multifactorial Disorders
Environmentally Induced Congenital Disorders
Diagnosis, Counseling, and Gene Therapy
Benign Versus Malignant Growth
Epidemiology and Cancer Risk Factors
Multistep Nature of Carcinogenesis
Chapter 8. Infectious Processes
Chapter 9. Inflammation and Immunity
Components of the Immune System
Chemical Mediators Of Immune Function
Innate Defenses and Inflammation
Systemic Manifestations of Inflammation
Major Histocompatibility Complex
Mechanisms of Cell-Mediated Immunity
Mechanisms of Humoral Immunity
Integrated Function and Regulation of the Immune System
Integrated Response To New Antigen
Chapter 10. Alterations in Immune Function
Primary Immunodeficiency Disorders
Secondary Immunodeficiency Disorders
Chapter 11. Malignant Disorders of White Blood Cells
Classification of Hematologic Neoplasms
Etiology of Myeloid and Lymphoid Neoplasms
General Principles of Management
Chapter 12. HIV Disease and AIDS
Monitoring the Progression of HIV
Unit IV: Oxygen Transport, Blood Coagulation, Blood Flow, and Blood Pressure
Chapter 13. Alterations in Oxygen Transport
Structure and Function of Red Blood Cells
Gas Transport and Acid-Base Balance
Anemia Related to Decreased Red Cell Production
Anemia Related to Inherited Disorders of the Red Cell
Anemia Related to Extrinsic Red Cell Destruction or Loss
Chapter 14. Alterations in Hemostasis and Blood Coagulation
Evaluation of Hemostasis and Coagulation
Vascular and Platelet Disorders
Chapter 15. Alterations in Blood Flow
Organization of the Circulatory and Lymphatic Systems
General Mechanisms That Cause Altered Flow
Chapter 16. Alterations in Blood Pressure
Mechanisms of Blood Pressure Regulation
Molecular Basis of Contraction
Determinants of Cardiac Output
Endocrine Function of the Heart
Chapter 18. Alterations in Cardiac Function
Endocardial and Valvular Diseases
Chapter 19. Heart Failure and Dysrhythmias: Common Sequelae of Cardiac Diseases
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