Nonspecific Granulomatous Orchitis



Nonspecific Granulomatous Orchitis


Steven S. Shen, MD, PhD

Jae Y. Ro, MD, PhD










Nonspecific granulomatous orchitis is shown. Bivalved testis with ill-defined nodules variably involve the testis and paratestis. Due to the pseudotumorous firm consistency, malignancy is mimicked.






Typical features of early stage are characterized by intratubular histiocytic infiltration with a few lymphocytes, mimicking granulomas. Special stains for microorganisms are negative.


TERMINOLOGY


Definitions



  • Mixed chronic and granulomatous orchitis with no specific etiology; may be autoimmune or posttraumatic reaction


ETIOLOGY/PATHOGENESIS


Unknown Causes



  • Trauma, infection, extravasated sperm, and autoimmune disease have been postulated as possible pathogenetic mechanisms



    • May be associated with urinary tract infection, history of prostatectomy, and inguinal hernia repair


    • Autoimmune reaction to sperm antibodies


    • Vascular compromise with ischemia or infarction


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare; more common in African-Americans


  • Age



    • Range: 29-79 years old (average: 55 years old)


Presentation

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Nonspecific Granulomatous Orchitis
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