Molecular Factors Index



Molecular Factors Index








































































































































































































































Molecular Factors Discussed


Molecular Factor


Chromosomal Location


Definition/Alternative Names


Chapters


12q13-15




Fibrous Dysplasia


16q22




Aneurysmal Bone Cyst


1p




Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


4p16.3




Giant Cell Reparative Granuloma


6q13




Chondromyxoid Fibroma


6q25




Chondromyxoid Fibroma


ALX4


11p11.2


ALX homeobox 4


Multiple Hereditary Osteochondromatosis


CDH11-USP6


t(16;17)(q21;p13)



Aneurysmal Bone Cyst


CDK4


12q14


cyclin-dependent kinase 4


Adipocytic Tumors


CIC-DUX4


t(4;19)(q35;q13.2)



Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


c-KIT


4q11-q12


KIT; CD117; tyrosine kinase KIT


Mast Cell Disease


Cytogenetic aberrations, other




Enchondroma; Osteofibrous Dysplasia


DDIT3


12q13.1-q13.2


DNA-damage-inducible transcript 3


Adipocytic Tumors


DYNC1H1


14q32


dynein, cytoplasmic 1, heavy chain 1


Plasmacytoma/Myeloma


E1AF


17q21


E1A enhancer-binding protein; ETV4


Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


ETV1


7p21.3


ets variant 1


Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


EWS (see EWSR1)


EWS-ERG


t(21;22)(q22.3;q12.2)



Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


EWSR1


22q12.2


Ewing sarcoma breakpoint region 1


Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET); Conventional Osteosarcoma; Myoepithelioma


EWSR1-FLI1


t(11;22)(q24;q12)



Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


EXT1


8q24.11


exostosin 1


Multiple Hereditary Osteochondromatosis; Osteochondroma


EXT2


11p12-p11


exostosin 2


Multiple Hereditary Osteochondromatosis; Osteochondroma


EXT3


19p


exostosin 3


Multiple Hereditary Osteochondromatosis; Osteochondroma


FEV


2q36



Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


FUS


16p11.2


fused in sarcoma


Adipocytic Tumors


FUS/ERG


t(16;21)(p11.2;q22.3)



Ewing Sarcoma/Primitive Neuroectodermal Tumor (PNET)


GNAS1


20q13.3


GNAS complex locus


Liposclerosing Fibromyxoid Tumor; Osteofibrous Dysplasia; Fibrous Dysplasia


IDH1


2q33.3


isocitrate dehydrogenase 1 (NADP+), soluble


Conventional Chondrosarcoma; Conventional Osteosarcoma; Dedifferentiated Chondrosarcoma; Enchondromatosis


IDH2


15q26.1


isocitrate dehydrogenase 2 (NADP+), mitochondrial


Conventional Chondrosarcoma; Conventional Osteosarcoma; Dedifferentiated Chondrosarcoma; Enchondromatosis


LEMD3


12q14


LEM domain containing 3


Bone Island/Osteopoikilosis; Melorheostosis


MDM2


12q15


p53 E3 ubiquitin protein ligase homolog (mouse)


Adipocytic Tumors; Melorheostosis


n-MYC


8q24


NMYC; neuroblastoma MYC


Multiple Hereditary Osteochondromatosis


RB1


13q14.2


retinoblastoma 1


Conventional Osteosarcoma


t(11;22)




Adamantinoma; Mesenchymal Chondrosarcoma


t(12;16)




Adipocytic Tumors


t(16;17)




Aneurysmal Bone Cyst


t(21;22)




Adipocytic Tumors


t(3;12)(q28;q14)




Adipocytic Tumors


t(5;17)




Chondroblastoma


t(X;18)




Solitary Fibrous Tumor/Hemangiopericytoma


TP53


17p13.1


tumor protein p53


Conventional Osteosarcoma


TRPS1


8q24.12


trichorhinophalangeal syndrome I


Multiple Hereditary Osteochondromatosis


USP6


17p13


ubiquitin specific peptidase 6


Aneurysmal Bone Cyst; Giant Cell Reparative Granuloma


WWTR1-CAMTA1


t(1;3)(p36.3;q25)



Epitheioid Hemangioendothelioma

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Jul 6, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Molecular Factors Index

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