Laxatives

Chapter 28


Laxatives






INDICATIONS



Laxatives are divided into five primary categories, which vary in terms of mechanism of action, potency, effect, indication, and cost. These five categories consist of bulk, stool softeners, osmotic, stimulants, and enemas.



Therapeutic Overview


Anatomy and Physiology


The large intestine contains a mixture of the remnants of several meals ingested over 3 to 4 days. The ascending colon holds the contents of the stomach for about an hour. The transverse colon is the primary site for processing feces. The descending colon is a holding tank and conduit for feces for about 24 hours. The sigmoid colon and the rectum act as reservoirs. The nerves responsible for the activation of mass movement are located in the descending colon. Skeletal muscles that maintain continence are located in the surrounding pelvic floor. The integrity of the nervous system is necessary for coordination of the defecation process.


Contractions occur almost continuously in the large intestine and are divided into two basic types. The segmental pattern of motility occurs in the transverse colon, where most of the removal of water and electrolytes occurs and feces are moved forward very slowly. The circular muscles are responsible for segmental contractions. Ring-like contractions divide the colon into chambers called haustra. Haustrations mix and compress the feces, facilitating absorption of water while moving the feces backward and slowly forward. The second type of contraction, the mass movement (power propulsion), is a different process that occurs in the transverse and descending colon to promote bowel movements. Evacuation is aided by (1) voluntary muscles of the abdomen that contract to promote propulsion, (2) relaxation of the circular muscles, with disappearance of haustral contractions, and (3) distention of the gut caused by increased contents of the bowel. The increase in mass movements after a meal is called the gastrocolic reflex.




Disease Process


Constipation is a very common complaint among individuals of all ages, leading to 2.5 million physician visits annually in the United States. Prevalence ranges from 2% to 27%.


Constipation means very different things to different patients. Often it is perceived as infrequent or difficult defecation. Some of these changes normally occur if a patient becomes less active or eats less food. The frequency of bowel movements in normal patients ranges from 3 to 12 a week. Changes in consistency are generally due to changes in the amount of fiber eaten. The objective definition of constipation is two or fewer bowel movements per week, or excessive difficulty and straining at defecation.


Chronic functional constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are both functional GI disorders. The definitions of these conditions, which are diagnosed on the basis of symptom criteria, were updated in 2005 with the use of the Rome III criteria. This framework is particularly helpful for categorizing symptoms in difficult cases. According to Rome III, symptoms must be present over the previous 3 months and must have an onset at least 6 months prior to the time of diagnosis. For CC, symptom criteria include straining, lumpy or hard stool, and a sense of incomplete evacuation. Patients also must have insufficient criteria to be given a diagnosis of IBS.


True clinical constipation includes the diagnostic findings of a large amount of feces in the rectal ampulla on digital examination and/or excessive fecal loading of the colon, rectum, or both on abdominal radiograph. Constipation can be acute or chronic, intermittent or continuous.


Constipation has many causes, ranging from inadequate fiber to colon cancer. Medications are an important cause (Table 28-1). Systemic disease may cause constipation through neurologic gut dysfunction, myopathies, and electrolyte imbalances. Diabetic patients may have autonomic nerve dysfunction. Structural causes can be the result of a congenital defect or the structural obstruction of a mass, which may be cancerous. Any sudden change in bowel habits warrants a thorough investigation. The primary cause is a disturbance in motility; secondary causes include medications, malignancy, and non-GI disease.



Irritable bowel syndrome (IBS) is characterized by a strong relationship between abdominal pain and defecation. Individuals with IBS have visceral hypersensitivity, or increased perception of gut-related events. In IBS, the onset of constipation generally corresponds with an onset of pain at defecation. In patients with functional constipation, some abdominal discomfort or even pain with defecation may occur if a long interval has passed since the last bowel movement, but pain is not a predominant or frequent symptom associated with defecation. Patients with IBS may report abdominal pain, even if they empty their bowels regularly. By definition, functional GI disorders are diagnosed on the basis of symptoms. For many patients, a complete history and physical examination will allow the clinician to make an accurate diagnosis.


Practitioners should ask specifically about any OTC laxatives that the patient has taken. Evaluate for laxative abuse. Prolonged and habitual use of laxatives can result in cathartic colon, thereby causing reliance on laxatives for a regular bowel movement. Laxative abuse syndrome (LAS) is difficult to diagnose; it often is seen in women with depression, personality disorder, or anorexia nervosa. Clinical features of laxative abuse include factitious diarrhea, electrolyte imbalance, osteomalacia, protein-energy malnutrition, cathartic colon, liver disease, and steatorrhea. Many agents can be detected in urine or stool samples.



Mechanism of Action


All laxatives work by increasing fluid retention in the colon, resulting in bulkier and softer stools; by decreasing absorption of luminal water through actions on the colonic mucosa; or by increasing intestinal motility. Expected results may take from 5 minutes to several days.





Osmotic Laxatives


Osmotic laxatives are largely nonabsorbable sugars, although small amounts may be absorbed. Bacteria metabolize these agents into lactic acid, formic acid, acetic acid, and carbon dioxide, which act via osmosis. This means that they are present in solution in higher concentration in the bowel, causing water to move from the tissue into the bowel to equalize osmotic pressure. The increased bulk increases colonic peristalsis. Most are disaccharides. Lactulose is a semisynthetic disaccharide of fructose and galactose. Sorbitol is a nonabsorbable sugar. However, glycerin is a naturally occurring trivalent alcohol suppository that acts via hyperosmotic action and through local irritation and lubrication. The American College of Gastroenterology (ACG) Task Force has named osmotic laxatives as among the most effective types.






Treatment Principles


Standardized Guidelines





image Constipation in children and young people. Diagnosis and management of idiopathic childhood constipation in primary and secondary care 2010. See http://guidance.nice.org.uk/CG99QuickRefGuide/pdf/English.





Nonpharmacologic Treatment


Nonpharmacologic measures are cost-effective and do not produce the complications associated with laxative use. These measures should be used in all patients with constipation, regardless of whether a medication is prescribed. No medication is an adequate replacement for these measures. Nonpharmacologic management of chronic constipation is encouraged for all ages, especially the young and the old. In the absence of disease, adequate colonic movements can be achieved by a regimen based on four basic components:



• First, adequate fluids are crucial both for laxatives to work and to prevent constipation, with 1500 ml/day minimum essential for maintaining normal bowel activity. Adequate fluids act by keeping fluid in the feces as it passes through the colon. This maintains the bulk of the feces and allows for normal transit. Fluids that are diuretics, such as those that contain caffeine, do not work as well to keep water in the feces. Flavored waters are often an acceptable substitute for plain water. However, data are lacking to support that an increase in fluids to greater than 1500 ml/day is effective in alleviating constipation.


• Second, a high-fiber diet is important. An adult should have a daily intake of 20 to 35 g of fiber; a child should receive 1 g per year of age plus 5 g/day after 2 years of age. This fiber is best obtained from high-roughage foods like bran or vegetables and fruits. See Table 28-3 for a list of foods that are high in fiber. Bran is the outer coating of various grains. The two most commonly found grains are wheat bran and oat bran, which have large amounts of fiber. Other whole grain, unpolished grains, and rice have the outer coating still on, have good amounts of fiber, and may be easier to tolerate than concentrated bran. Sudden increases in fiber in the diet can cause bloating and gas. A high-fiber diet is better tolerated if the change is made gradually. Enough fiber can also be obtained through the regular use of bran slurry (see Box 28-1 for ingredients). Start with 1 tablespoon a day and work up to 3 tablespoons twice a day as needed. It can be mixed with cereal or other foods. Make sure the patient continues to drink enough fluids.



BOX 28-1   Recipes to Reduce Constipation


A Bran Slurry Recipe


3 cups applesauce (low sugar)


2 cups wheat or oat bran


1½ cups unsweetened prune juice




• Third, patients should establish and maintain a regular exercise schedule. Any type of activity is helpful. Simply walking briskly every day facilitates digestion and keeps muscles of the body better toned.


• Fourth, a regular toileting schedule should be established. This includes going to the toilet at the same time each day, 15 to 45 minutes after a meal. Patient should allow for 10 to 15 minutes on the toilet without interruption, stress, or the need to hurry. Patients should not ignore or postpone the urge to defecate.


• Fluids, fiber, and exercise, which help most people, are not applicable to the very aged, the frail elderly, and those wheelchair- or bed-bound. Other individuals with CHF are unable to tolerate these mechanisms. It is essential for clinicians to know their patients and assess what is reasonable for them to do.



Pharmacologic Treatment


Pharmacologic treatment may be added if nonpharmacologic treatment is not sufficient, or when immediate or thorough cleansing is indicated. Selection is based on matching the patient characteristics to the effects of the different categories of laxatives. Important factors that should be considered include the cause of constipation, long- or short-term use, severity of constipation, age of the patient, oral food and fluid intake, and prior laxative use (see Table 28-2). Polyethylene glycol and lactulose are recognized as highly effective.


One important decision involves the medication formulation. Remedies are available as oral agents, rectal suppositories, and enemas. Oral formulations may come in tablet, capsule, syrup, powder, or liquid form. Some forms are dissolved in water. Oral treatment is selected for long-term use; it is essential for the clinician to find a formulation that the patient is willing and able to tolerate on a long-term basis. Oral medications also can be used on a short-term basis for severe constipation. Rectal suppositories and enemas should be used only for short-term management because irritation of the rectum can occur with long-term use.



Management



Short Term



• Short-term constipation, whether occasional or caused by external factors, is treated with a short-acting laxative. Another short-term use for laxatives involves preparation for surgery or another procedure.


• Mild short-term constipation can be treated with bulk laxatives or a saline agent such as Milk of Magnesia.


• If the patient is severely constipated or has not responded to increased fiber intake, he might need an enema or one of the more potent laxatives. Saline laxatives such as Milk of Magnesia are suggested as second-line treatment by the AGA. Enemas are useful when the patient has stool in the rectum but is unable to push it out. If the patient is impacted, he must be manually disimpacted before any laxative is used. Stimulant laxatives are used for constipation that occurs higher in the colon and should be considered third-line agents.


• If the patient has chronic constipation with a short-term exacerbation, long-term management will be necessary.

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Jul 22, 2016 | Posted by in PHARMACY | Comments Off on Laxatives

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