Large Cell Calcifying Sertoli Cell Tumor

Large Cell Calcifying Sertoli Cell Tumor

Steven S. Shen, MD, PhD

Jae Y. Ro, MD, PhD

A well-circumscribed LCCSCT is demarcated from the adjacent testis image by a thick fibrous capsule. The tumor is composed of cords and nests of tumor cells with hyalinized or myxoid stroma.

A LCCSCT is shown with cords of large epithelioid cells containing abundant eosinophilic cytoplasm. The hallmark of this tumor is the presence of scattered calcifications image.



  • Large cell calcifying Sertoli cell tumor (LCCSCT)


  • Variant of Sertoli cell tumor with large epithelioid cells and peculiar calcifications, often associated with clinical syndromes



  • Incidence

    • Extremely rare, < 60 have been reported

  • Age

    • Range: 1.5-48 years (average: 16 years)


  • Slowly enlarging, painless testicular mass

  • Sporadic (60%) or as a component of Carney and Peutz-Jeghers syndromes

  • Some patients may have gynecomastia or precocious puberty

  • Acromegaly or gigantism may be seen due to associated pituitary adenoma

  • Association with cardiac myxoma or sudden death

  • May be associated with adrenocortical hyperplasia, hypercortisolemia, or testicular Leydig cell tumor

  • High frequency of bilaterality (40%) and multifocality (60%)

  • Intratubular LCCSCT is a variant of LCCSCT occurring in boys with Peutz-Jeghers syndrome; often estrogenic, bilateral and multifocal; always benign

  • Malignant form: Mean age: 39 years; more often unilateral and solitary compared to benign tumors


  • Surgical approaches

    • Orchiectomy is usually curative; long-term followup is necessary


  • Excellent, but some (20%) may have malignant behavior


Radiographic Findings

  • Ultrasound may detect testicular mass with brightly echogenic area (calcification)

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Large Cell Calcifying Sertoli Cell Tumor

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