Juvenile Granulosa Cell Tumor



Juvenile Granulosa Cell Tumor


Steven S. Shen, MD, PhD

Jae Y. Ro, MD, PhD










JGCT, which is relatively well circumscribed from the surrounding testis image, is composed of multicystic follicular spaces lined by multilayers of granulosa cells image containing basophilic fluid.






JGCT has solid and follicular areas composed of cells with uniform round to oval nuclei and moderate cytoplasm. Prominent extracellular and intraluminal basophilic mucinous material is present.


TERMINOLOGY


Abbreviations



  • Juvenile granulosa cell tumor (JGCT)


Definitions



  • Testicular tumor that is multicystic and composed of multiple follicles lined by granulosa and theca-like cells occurring predominantly in infants


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Extremely rare in testis


    • Most common testicular tumor in infants


    • 6.6% of all prepubertal testicular tumors


  • Age



    • Infants younger than 2 years (most younger than 6 months)


    • Rarely occurs in adults


Presentation



  • Painless scrotal or abdominal mass


  • Associations



    • Undescended testes


    • Gonadal dysgenesis with chromosomal abnormality affecting Y chromosome or 45X/46XY mosaicism (Denys-Drash syndrome)


  • Contralateral testis is often undescended


  • No known presentation with gynecomastia or endocrine disorders


Treatment



  • Surgical approaches



    • Orchiectomy is curative


    • Partial orchiectomy (testis sparing) may be option


Prognosis



  • Clinically benign


  • Malignant behavior or metastasis has not been reported


IMAGE FINDINGS


General Features



  • Complex, multiseptated, hypoechoic mass on ultrasonography


MACROSCOPIC FEATURES


General Features



  • Well-circumscribed or partially encapsulated multicystic mass with solid yellow and papillary areas


Size



  • Range: 0.8-6.0 cm

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Juvenile Granulosa Cell Tumor
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