Granular Histiocytic Reacton
Julie C. Fanburg-Smith, MD
Aaron Auerbach, MD
Key Facts
Terminology
Post-surgery collections of histiocytes with granular cytoplasm collecting at site of surgical trauma
Microscopic Pathology
Histiocytes with granular, eosinophilic cytoplasm
Fringe of histiocytes around core of granular/amorphous material
Autofluorescent
Acid fast with Ziehl-Neelsen stain
Top Differential Diagnoses
Granular cell tumor
Rosai-Dorfman disease
Langerhans cell histiocytosis
Diagnostic Checklist
CD163(+), CD68(+)
Negative for S100 and other markers
Sheets of granular histiocytes without atypia or mitotic activity
 Hematoxylin & eosin shows sheets of granular histiocytes in a woman who had previously undergone abdominal surgery. |
 Hematoxylin & eosin shows sheets of granular histiocytes around iatrogenic hemostasis material from a previous surgery. |
TERMINOLOGY
Abbreviations
Granular histiocytic reaction (GHR)
Synonyms
Reactive granular cells
Postsurgical granular reactions
Definitions
Post-surgery collections of histiocytes with granular cytoplasm
Collect at site of surgical trauma
CLINICAL ISSUES
Epidemiology
Incidence
Rare
Age
Usually adults
Gender
