Gestational Trophoblastic Disease


QUESTION 49.1






A.  Diploidy (46,XX or 46,XY)



B.  Normal volume of uterus



C.  No significant risk of choriocarcinoma



D.  Parthenogenetic origin



E.  Triploidy (69,XXX or 69,XXY)





  2.  The products of conception from a 20-week gestation are analyzed by p57 immunohistochemistry. Expression of p57 is detected in villous trophoblast and stromal cells. Subsequently, genotyping demonstrates biparental diploidy, with one chromosomal complement from the father and one from the mother. These findings are consistent with:




A.  Complete mole



B.  Incomplete mole



C.  Nonmolar pregnancy




  3.  An exaggerated placental site is found in up to 2% of first-trimester abortions. This benign lesion is characterized by an increased number of:




A.  Cytotrophoblastic cells



B.  Intermediate trophoblastic cells



C.  Smooth muscle cells



D.  Syncytiotrophoblastic cells



E.  All of the above




  4.  Which of the following statements is true about the gestational trophoblastic disease depicted in this photomicrograph?



Image


QUESTION 49.4




A.  Develops most frequently from ectopic pregnancy



B.  Most cases follow partial mole



C.  Poorly responsive to chemotherapy



D.  Rarely metastasizes to the brain



E.  Risk is influenced by blood group




  5.  One year after a term pregnancy, a 40-year-old woman undergoes hysterectomy because of a neoplasm infiltrating the uterine fundus to the serosa. Its histologic appearance is shown in this photomicrograph. Cells are immunoreactive for HSD3B, cytokeratin, and human placental lactogen (hPL), but negative for p63. The Ki-67 labeling index is approximately 15%. This tumor is a:



Image


QUESTION 49.5




A.  Choriocarcinoma



B.  Epithelioid trophoblastic tumor



C.  Exaggerated placental site



D.  Placental site nodule



E.  Placental site trophoblastic tumor

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Dec 23, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Gestational Trophoblastic Disease
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