Follicular Dendritic Cell Sarcoma

Follicular Dendritic Cell Sarcoma

Cyril Fisher, MD, DSc, FRCPath

Hematoxylin & eosin shows sheets of ovoid tumor cells with admixed adherent lymphocytes and prominent blood vessels.

Hematoxylin & eosin shows neoplastic cells that have distinctive oval nuclei with speckled chromatin, small nucleoli, and prominent nuclear membrane image. Indistinct cell margins give syncytial look.



  • Follicular dendritic cell sarcoma (FDCS)


  • Dendritic reticulum cell sarcoma


  • Malignant tumor of follicular dendritic cells

    • Antigen-trapping cells of accessory immune system

    • Normally in germinal center of lymph node


Varied Etiologies

  • Most cases arise de novo

  • 10-15% arise in hyaline-vascular-type Castleman disease

    • Antecedent dendritic cell hyperplasia and dysplasia

  • Inflammatory pseudotumor-like variant is associated with EBV



  • Age

    • Young and middle-aged adults

  • Gender

    • Slight female predominance


  • Majority involve lymph nodes

    • Neck, mediastinum

    • Spleen, tonsil

    • Liver

  • Inflammatory pseudotumor-like variant

    • Females, in liver or spleen

  • Over 1/3 arise in extranodal sites

    • GI tract: Stomach, colon

    • Mesentery, mesocolon, mediastinum

    • Head and neck: Pharynx, palate

    • Soft tissue sites: Neck, axilla, breast


  • Painless mass

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Follicular Dendritic Cell Sarcoma

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