Epithelioid Hemangioma

Epithelioid Hemangioma

Steven D. Billings, MD

Hematoxylin & eosin shows a low-power view of epithelioid hemangioma demonstrating vascular proliferation in association with lymphoid aggregates image.

Hematoxylin & eosin shows capillaries lined with epithelioid endothelial cells admixed with numerous eosinophils image.



  • Angiolymphoid hyperplasia with eosinophilia, histiocytoid hemangioma


  • Benign vascular tumor with epithelioid endothelial cells, usually accompanied by lymphoid aggregates and eosinophils



  • Dermal or subcutaneous nodules

  • Most commonly involves head and neck, especially around ear

  • Usually solitary but may be multiple in same region


  • Benign

    • Local recurrence in up to 1/3

    • No metastasis


Histologic Features

  • Lobular proliferation of capillaries usually surrounding central vessel

    • Capillaries lined by epithelioid endothelial cells

    • Epithelioid endothelial cells with abundant eosinophilic cytoplasm

    • Not all vessels necessarily have epithelioid endothelial cells

  • Lymphoid aggregates

    • May show germinal center formation

  • Abundant eosinophils

  • Usually superficial dermal tumors

  • Rare deep or intravascular tumors

  • Endothelial cells positive for CD31 and CD34

    • Immunohistochemical stains can bring out hard-to-see vascular component in cases with obscuring lymphoid aggregates

Predominant Cell/Compartment Type

  • Vascular

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Epithelioid Hemangioma
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