Epithelioid Hemangioma



Epithelioid Hemangioma


Steven D. Billings, MD









Hematoxylin & eosin shows a low-power view of epithelioid hemangioma demonstrating vascular proliferation in association with lymphoid aggregates image.






Hematoxylin & eosin shows capillaries lined with epithelioid endothelial cells admixed with numerous eosinophils image.


TERMINOLOGY


Synonyms



  • Angiolymphoid hyperplasia with eosinophilia, histiocytoid hemangioma


Definitions



  • Benign vascular tumor with epithelioid endothelial cells, usually accompanied by lymphoid aggregates and eosinophils


CLINICAL ISSUES


Presentation



  • Dermal or subcutaneous nodules


  • Most commonly involves head and neck, especially around ear


  • Usually solitary but may be multiple in same region


Prognosis



  • Benign



    • Local recurrence in up to 1/3


    • No metastasis


MICROSCOPIC PATHOLOGY


Histologic Features



  • Lobular proliferation of capillaries usually surrounding central vessel



    • Capillaries lined by epithelioid endothelial cells


    • Epithelioid endothelial cells with abundant eosinophilic cytoplasm


    • Not all vessels necessarily have epithelioid endothelial cells


  • Lymphoid aggregates



    • May show germinal center formation


  • Abundant eosinophils


  • Usually superficial dermal tumors


  • Rare deep or intravascular tumors


  • Endothelial cells positive for CD31 and CD34



    • Immunohistochemical stains can bring out hard-to-see vascular component in cases with obscuring lymphoid aggregates


Predominant Cell/Compartment Type



  • Vascular

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Epithelioid Hemangioma
Premium Wordpress Themes by UFO Themes
%d bloggers like this: