Endometriosis



Endometriosis




General Considerations


Endometriosis affects 10%-15% of menstruating women between ages of 24 and 40 years. Main risk factor is heredity—a mother or sister with endometriosis. Other risk factors include shorter menstrual cycles; longer duration of flow; lack of exercise from an early age; high-fat diet; intrauterine device use; estrogen imbalance; natural red hair color; personal history of abuse; pelvic immune action with antibody to sperm; immune dysfunction; prenatal exposure to estrogens, xenoestrogens, or endocrine disruptors (polychlorinated biphenyls [PCBs], weed killers, plastics, detergents, household cleaners, aluminum can liners), or dioxin; liver dysmetabolism of estrogens. Endometriosis can cause infertility and miscarriage, producing excess free radicals involved in implantation. Endometriomas (ectopic endometrium on ovaries) are found in two thirds of endometriosis patients. Infertility may cause endometriosis from tubal scarring, adhesions, unruptured follicles.



Diagnostic Considerations




• Symptoms begin at onset of menstruation or later, worsening with time. Triad of symptoms: dysmenorrhea, dyspareunia, infertility. Features include acute pain before menses, lasting a day or two during menses or throughout the month; vomiting; diarrhea; fainting concurrent with pelvic/abdominal cramping and labor-like pains; chronic bearing down pain; pressure on low back; pains radiating down legs; pain with urination or bowel movements; bleeding from nose, bladder, or bowels; fatigue.


image


• Curious feature: pain and extent of disease correlate poorly. Symptom severity correlates with depth of lesions rather than number of lesions.


• Physical examination: one or more of the following: tenderness in pelvic area and/or cul-de-sac; enlarged or tender ovaries; uterus tips backward and lacks mobility; fixed pelvic structure; adhesions. Other findings include endometrial tissue or surgical scar tissue in vagina or on cervix. Examination during the first or second day of menses: tender septum between rectum and vagina.


• Pelvic ultrasound: useful assessing pain and tumors but not definitive; detects mass on ovary; determines size, characteristics, consistency of endometriosis. Blood test CA-125 can be positive in endometriosis but cannot distinguish endometriosis, fibroids, malignancies, and even normal tissue.


• Definitive diagnosis: biopsy by laparoscopy or laparotomy of visualized tissue.


• Estrogens stimulate growth of implants: therapy manipulating endogenous hormones may be effective.



Therapeutic Considerations


Diet




• Objectives:



• High-fiber foods optimize intestinal transit time and balance friendly gut microflora that displace undesirable strains that deconjugate estrogens, allowing them to recirculate. Less protein, high-fiber organic vegetarian diet: decreases plasma active unconjugated estrogens; reduce intake of proinflammatory arachidonic acid. Vegetable protein, soy, nut butters (almond), salmon are preferred. Emphasize phase 2 liver support vegetables: carrots, beets, artichokes, lemons, dandelion greens, watercress, bur-dock root, cabbage family vegetables. Indole-3-carbinol, in broccoli, Brussels sprouts, cabbage, cauliflower, favors less-active estrogen metabolites. Onions, garlic, and leeks contain immunity-enhancing organosulfur compounds and bioflavonoids (quercetin) that protect against oxidation, block inflammation, and inhibit tumor growth.


• Phytoestrogens: soy isoflavones and flaxseed lignans help alleviate endometriosis symptoms.


• Seasonings: Turmeric (curcumin) protects against environmental carcinogens, decreases inflammation, increases bile secretion. Milk thistle seeds soaked and ground helps liver function. Fresh flaxseeds increase antiinflammatory fatty acids. Fucus (seaweed) stimulates T-cell production and absorbs toxins.


• Decrease sugar, caffeine, dairy, red meat, alcohol.

Stay updated, free articles. Join our Telegram channel

Apr 3, 2017 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Endometriosis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access