2.  The microscopic findings of a bone marrow biopsy from a 40-year-old patient with AIDS are shown in this photomicrograph. Besides AIDS, this characteristic change is associated most commonly with:

  3.  A trephine biopsy shows entirely necrotic tissue. Which of the following conditions is the most frequent cause of necrosis in bone marrow biopsies?

  4.  A bone marrow biopsy from a 30-year-old male with fever of unknown origin reveals several lesions such as the one shown in this photomicrograph. Culture studies and special stains for infectious organisms are carried out. The most common etiology of such lesions in bone marrow biopsies is:

  5.  A bone marrow biopsy from an AIDS patients presenting with severe anemia and reticulocytopenia reveals intranuclear inclusions in numerous erythroid precursors, as shown in this photomicrograph. Which of the following is the infectious agent?

  6.  A bone marrow biopsy is performed in a patient with clinical and hematologic findings suggestive of acute leukemia. Which of the following morphologic features allows distinguishing acute myeloid leukemia (AML) from acute lymphocytic leukemia (ALL)?

  7.  Which of the following studies provides the most important prognostic indicators in acute leukemias?

  8.  Which of the following are the chemotherapeutic compounds that most frequently cause acute leukemias?

  9.  A 58-year-old male undergoes bone marrow examination because of blood cytopenia without apparent cause. The bone marrow is hypercellular with an increased number of myeloid precursors and marked erythroid hyperplasia. Clusters of immature myeloid precursors are seen in an abnormal location, far from bone trabeculae. Which of the following is the most likely diagnosis?

10.  This photomicrograph shows the most typical bone marrow findings in:

11.  This photomicrograph shows the most typical bone marrow findings in:

12.  This photomicrograph shows the most typical findings in:

13.  Systemic mast cell disease is clinically suspected in a 67-year-old female patient. A bone marrow biopsy reveals multiple foci of abnormal cell infiltrates such as the one shown in this high-power picture. Which of the following special techniques is most useful to confirm bone marrow involvement by mast cell disease?

14.  A bone marrow biopsy is performed for staging of a non-Hodgkin lymphoma (NHL). Histologic examination reveals a focal paratrabecular pattern of marrow involvement. This pattern is most consistent with:

15.  With respect to evaluation of bone marrow involvement by Hodgkin lymphoma (HL), which of the following is correct?