Crystal-Storing Histiocytosis

Crystal-Storing Histiocytosis

Cyril Fisher, MD, DSc, FRCPath

Crystal-storing histiocytosis involving the lung of a patient with myeloma displays sheets of polygonal or spindled histiocytes that infiltrate inflamed loosely fibrous stroma, separating lung structures image.

Higher magnification shows aggregate of large polygonal histiocytes. The eosinophilic cytoplasm is distended by sheaves of crystalline structures image.



  • Crystal-storing histiocytosis (CSH)


  • Soft tissue aggregate of macrophages containing crystalline material


Paraneoplastic Phenomenon

  • In B-cell lymphoreticular neoplasia

    • Lymphoplasmacytoid lymphoma

    • Chronic lymphocytic leukemia

    • Extranodal marginal zone lymphoma

    • MALT lymphoma

    • Plasma cell dyscrasias

      • Monoclonal gammopathy

      • Myeloma

  • Mastocytosis

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Crystal-Storing Histiocytosis
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