Fig. 1.1 Chemical structure of some exogenous and endogenous agonists of the transient receptor potential vanilloid type-1 (TRPV1) capsaicin receptor The first paper on studying the pharmacological effects of capsaicin was…
Study, duration n Age (years) Sex (M:F) OA site Formulation Outcomes Rate of application site burning Deal 1991 (Deal et al. 1991) 4 weeks 70 61 25M:45F Knee 0.025 % capsaicin VAS…
Fig. 3.1 Schematic Representation of TRPV1 LTD. a Presynaptic TRPV1 LTD, while mediated at the presynaptic terminal depressing glutamate neurotransmitter release, requires formation of postsynaptic 12-HPETE in order to activate TRPV1….
Peripheral neuropathic conditions treated with Topical capsaicin Postherpetic neuralgia (PHN) Painful diabetic polyneuropathy (PDPN) HIV-associated distal symmetrical polyneuropathy (HIV-DSPN) Persistent postsurgical pain 4.2 Neuropathic Pain Whether noted by clinician or…
Route Treatment Proposed mechanism of action Observation Spontaneous voiding – Oral Antimuscarinics Suppresses detrusor muscle contractions Tricyclic antidepressant Central and peripheral anticholinergic Catheterization Intermittent Drainage of bladder/urinary tract Condom (male)…
Dermatologic condition Clinical manifestations Post-herpetic neuralgia Pain persisting more than 90 days following the occurrence of herpes zoster infection Notalgia paresthetica Focal pruritus typically located unilaterally on the mid- or upper…
Omar M. E. Abdel-Salam (ed.)Progress in Drug ResearchCapsaicin as a Therapeutic Molecule201410.1007/978-3-0348-0828-6_7 © Springer Basel 2014 7. Capsaicin as an Anti-Obesity Drug Felix W. Leung1, 2, 3 (1) 111G, Division of Gastroenterology, Sepulveda Ambulatory Care Center,…
Fig. 2.1 Critical residues involved in TRPV1 function. TRPV1 topology highlighting residues implicated in the activation, sensitisation, desensitisation, gating properties or permeation of the channel 2.6.1 The N Terminus Like other…
Fig. 6.1 Outlines the hypothetical mechanisms of AR, NAR, or MR and the role of capsaicin in TRPV1 desensitization in such clinical conditions. Stimulation of maxillary division of trigeminal nerves (V2)…
Fig. 5.1 Potential for TRPV1 modulation to reduce pain related to opioid-induced hyperalgesia. Either capsaicin-based defunctionalization or outright TRPV1 antagonism may be useful in alleviating this subset of chronic pain Further…
