Figure 72.1 Mechanism of action of aminoglycosides. A, Protein synthesis begins with binding of the 50S and 30S ribosomal subunits to messenger RNA (mRNA), followed by attachment of the first amino acid…

Figure 13.1 Structures of representative catecholamines and noncatecholamines. Catecholamines: All of the catecholamines share the same basic chemical formula. Because of their biochemical properties, the catecholamines cannot be used orally, cannot cross…

50–400 mg every 2–4 wkTransdermal patchTestosteroneAndrodermOne patch/day (delivers 2 or 4 mg/24 hr)IIIApplied to the arm, back, abdomen, or thigh, but not the scrotum. Causes local irritation.Transdermal gelTestosteroneAndroGel, Testim5–10 g…

Figure 86.1 Anatomy of the ear. The purple arrows indicate flow of the mucociliary system, which can transport bacteria out of the middle ear.  Otitis Media and Its Management Otitis media (OM),…

to adult dose PolycarbophilFiberCon, othersTablets Adults: 1250 mg 1–4 times a day Children 6–12 yr: 625 mg 1–4 times a daySURFACTANTDocusate sodiumColace, othersCapsules, tablets, syrup, liquid Adults and children older…

Mild Aspirin or aspirin combinations Triptans Moderate Dihydroergotamine (DHE) Ergotamine NSAID combination products Severe Metoclopramide Triptans Ergotamine or DHE NSAIDs (Ketorolac) Prophylaxis Beta blockers Tricyclic antidepressants Antiepileptics Consider hormonally related…

Figure 83.1 Flow chart for pain management in patients with cancer. NSAID, nonsteroidal antiinflammatory drug. (Adapted from Jacox A, Carr DB, Payne R, et al. Management of Cancer Pain [Clinical Practice Guideline No….

Cephalosporin Cephalexin Carbapenem Imipenem Other Vancomycin Third-Generation Cephalosporins Because they are highly active against gram-negative organisms, and because they penetrate to the CSF, third-generation cephalosporins are drugs of choice for…

Black Box Warning: Iron Dextran This preparation should be used for treatment of iron deficiency only in patients in whom oral administration is infeasible or ineffective due to increased risk…

] is an alpha1 blocker with selectivity for alpha1 receptors in the prostate and urinary tract. At recommended doses, blockade of alpha1 receptors on blood vessels is weak. Therefore, alfuzosin…