(4.1) Clearly, this model is limited by the size of the data set used. Nevertheless, this model is significant and interesting as it introduces nonlinearity (as log K ow2) into…

(3.1) where the terms used are shown in Fig. 3.1. This expression indicates that, at long times, there is a steady-state flux of (A 1 k 12 k 23)/(k 21 + k 23)…

Fig. 8.1 Schematic representation of flux and cumulative absorption profiles for a finite-dose application to human skin (© Williams (2003), used with permission) Designing in vitro experiments that accurately reflect this…

(7.1) where (7.2)is the permeation coefficient of the lipid fraction of the stratum corneum, (7.3)is the permeation coefficient of the protein fraction of the stratum corneum, and (7.4)where K ow…

(6.1) where P is the partition coefficient of the permeant between the membrane and the donor vehicle; C is the concentration (in this case, the solubility) of the permeant in…

(5.1) where J mss is the maximum steady-state flux (μ mol/s/cm2); J mss is the maximum steady-state flux (μ mol/s/cm2); e H is the charge value on a hydrogen with charge higher…

Fig. 1.1 Schematic diagram of the skin (© Williams (2003), used with permission) On average, human skin contains 40–70 hair follicles and 200–250 sweat ducts per square centimetre of skin. The…

Fig. 9.1 A comparison of experimental permeability for a series of captopril carboxyl ester prodrugs with the QSAR models of skin permeability proposed by Moss and Cronin (2002), Potts and Guy…