Treatment with Antidepressants The modern history of antidepressants began with the introduction of the tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) in the 1950s. Although these agents are now…
Indications for Antidepressants Depressive Disorders Depression is one of the most debilitating and common illnesses in medicine, having a major negative impact on personal, social, and occupational functioning. By the…
Treatment with Antipsychotics As in other areas of clinical science, serendipity as well as careful investigation contributed to our knowledge about antipsychotics, including their Discovery Potential mechanisms of action Range…
Indications for Antipsychotics The indication for antipsychotics is the presence of psychosis in such disparate disorders as Schizophrenia Schizophreniform disorder Schizoaffective disorder Delusional disorder Brief psychotic disorder Psychosis secondary to…
Assessment of Drug Efficacy and Relevant Clinical Issues A series of related issues is pertinent to the decision-making process a clinician uses in the application of drug therapy The first…
Pharmacodynamics and Pharmacokinetics General Principles The effect of any medication is determined by three variables: Affinity for and intrinsic activity at a site of action (pharmacodynamics, variable 1) Drug concentration…
General Principles The science of psychopharmacotherapy continues to rapidly expand, creating both an opportunity and a challenge. As the neurosciences facilitate the development of new psychotropics, the art of applying…
When it is necessary to control the environment, specifications for parameters such as temperature, humidity, colony-forming units (CFUs), and particulates per cubic foot should be…
Inactive Ingredients (Excipients) Excipients are defined as ingredients added to the drug formulation for purposes other than the therapeutic or medicinally active effect. They are largely inert substances that…
