© Springer International Publishing Switzerland 2016Edoardo Spina and Gianluca Trifirò (eds.)Pharmacovigilance in Psychiatry10.1007/978-3-319-24741-0_14 14. Safety of Psychotropic Drugs in the Elderly Kate L. Lapane1 , Anne Hume2, 3 , Christine Ulbricht1 and Giovanni Gambassi4 (1) Department of Quantitative Health Sciences, Division of…
Lithium N (%) Therapeutic agent toxicity 601 (2.3 %) Tremor 525 (2.01 %) Drug interaction 477 (1.82 %) Confusional state 337 (1.29 %) Completed suicide 299 (1.14 %) Drug…
Common Less common Rare Anxiety Muscle pain Convulsions Insomnia Vomiting Delirium Dysphoria Hyperacusis Psychotic symptoms Excitability Photophobia Delusions Poor memory and concentration Altered sensation Hallucinations Dizziness Depersonalization Mania Gastrointestinal problems…
Drug D2 5HT2A M H1 Alpha-1 Adverse side-effect association Reference compound Spiperone 4 – – – – EPS, tardive dyskinesia, prolactin Ketanserin – 4 – – – Rhabdomyolysis 3-quinuclidinyl-4-iodobenzilate (QNB)…
Antidepressant class adjusted hazard ratio (95 % CI) SSRIs TCAs Others Not taking antidepressants Adverse outcomes All-cause mortality 1.54 (1.48–1.59) 1.16 (1.10–1.22) 1.66 (1.56–1.77) 1.00 Attempted suicide/self-harm 2.16 (1.71–2.71)…
CPRD THIN IPCI BIFAP HSD Arianna Pedianet Country/region UK UK The Netherlands Spain Italy Italy Italy Population General population, including adults and children Pediatric and adult population Pediatric population…
Year withdrawn Drug (generic name) Reason withdrawn 1982 Clomacron Hepatotoxicity (UK) 1983 Zimeldine Hypersensitivity, Guillain-Barre syndrome (worldwide) 1986 Nomifensine Hemolytic anemia (worldwide) 1991 Triazolam Depression, amnesia (UK, France, and other…
© Springer International Publishing Switzerland 2016Edoardo Spina and Gianluca Trifirò (eds.)Pharmacovigilance in Psychiatry10.1007/978-3-319-24741-0_1 1. Pharmacovigilance in Psychiatry: An Introduction Edoardo Spina1 , Gianluca Trifirò1 and Achille Patrizio Caputi1 (1) Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy…
Fig. 3.1 Dilution bias: cumulative (left) and instantaneous (right) reporting rates for death by suicide among all reports for three antidepressants in the UK. After a TV show discussed this…
Imaging modality Setting (labs vs intensive care units, interventional or operating room) Feasibility (selective criteria; renal function) Accuracy in wall evaluation and non mobile atheroma Accuracy in wall evaluation and…
