Fig. 15.1 (a) Vessel wall, with deposits of amyloid, in renal AL amyloidosis. Congophilia (salmon-pink color) is noted in the vessel wall, corresponding to amyloid deposits. Congo red stain, bright…
Fig. 35.1 AIns amyloidosis secondary to subcutaneous insulin injection to control diabetes. The incisional subcutaneous biopsy shows extensive deposition of eosinophilic extracellular material in the subcutaneous adipose tissue (low and…
Fig. 27.1 Gene sequencing for ApoA1 showing c. 296T>C, p. Leu99Pro pathogenic mutation in exon 4. The top and bottom sequences (1 and 4) are the reference sequences against which…
Fig. 6.1 Prevalence of β2 mamyloid deposits at autopsy according to duration of dialysis. The autopsy was performed on osteoarticular specimens obtained from 54 deceased patients who had received long-term…
Organized deposits Non-organized deposits Type-1 cryoglobulinemic GN Light and heavy chain deposition disease (LHCDD) Immunotactoid GN Proliferative GN with monoclonal Ig deposits(PGNMID) Light and heavy chain amyloidosis (Fibrillary GN) Nonproliferative…
Age and sex at dx Interval from symptoms to dx How long did it take to type it Initial symptoms What bx was diagnostic, how many? What was your life…
© Springer International Publishing Switzerland 2015Maria M. Picken, Guillermo A. Herrera and Ahmet Dogan (eds.)Amyloid and Related DisordersCurrent Clinical Pathology10.1007/978-3-319-19294-9_39 39. Medicolegal Issues of Amyloidosis Timothy Craig Allen1 (1) Department of Pathology, The University of Texas Medical Branch,…
Anti-TNF medication Type Administered Diseases treated AA amyloidosis treatment Infection risk Use with caution in patients with Monitoring Antibody, autoimmune associations Etanercept Soluble p75 TNFR:Fc fusion protein Subcutaneous RA AS…
Drug Toxicity Melphalan (Alkeran) (oral) Bone marrow suppression Myelodysplastic syndrome Melphalan (IV with stem-cell rescue) Bone marrow suppression Infection Bortezomib (Velcade) Neuropathy Lenalidomide (Revlimid) Thrombocytopenia GI dysmotility Deep venous thrombosis…
Fig. 2.1 Mechanisms of amyloid formation and toxicity. Intrinsic instability, increased concentration, mutations, proteolytic cleavage or a combination thereof can favour the conversion of the amyloidogenic precursor into its misfolded…
