Well-differentiated Neuroendocrine Neoplasm, Ampulla Vikram Deshpande, MD Key Facts Etiology/Pathogenesis Syndromic cases associated with neurofibromatosis, MEN1, Zollinger-Ellison syndrome Clinical Issues Behavior/prognosis difficult to predict Size, mitotic rate are poor predictors…
Ampullary Adenocarcinoma and Variants Mari Mino-Kenudson, MD Key Facts Terminology Ampullary adenocarcinoma comprises both adenocarcinomas arising in ampullary region and periampullary duodenal adenocarcinomas Clinical Issues 5-year survival rate after surgical…
Ampullary Adenoma Mari Mino-Kenudson, MD Key Facts Clinical Issues Most are sporadic Seen in 50-95% of patients with (FAP) and Gardner syndrome Macroscopic Features May involve one or more parts…
Exocrine Pancreas Cancer Protocol Laura Webb Lamps, MD Pancreas (Exocrine): Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Head of pancreas ____ Body of pancreas…
Endocrine Pancreas Cancer Protocol Laura Webb Lamps, MD Pancreas (Endocrine): Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen ____ Head of pancreas ____ Body of pancreas ____ Tail of pancreas…
Solid-Pseudopapillary Tumors Grace E. Kim, MD Key Facts Terminology Solid-pseudopapillary tumor (SPT) Low-grade malignant neoplasm of uncertain cellular differentiation Etiology/Pathogenesis 90-100% harbor mutations in β-catenin gene Clinical Issues Occurs predominately…
Well-differentiated Neuroendocrine Neoplasm, Pancreas Vikram Deshpande, MD Key Facts Etiology/Pathogenesis MEN1 von Hippel-Lindau syndrome Tuberous sclerosis Sporadic Clinical Issues Surgical resection remains mainstay of therapy for tumors confined to pancreas…
Poorly Differentiated Neuroendocrine Carcinoma, Pancreas Vikram Deshpande, MD Key Facts Clinical Issues Very aggressive neoplasms Patients may benefit from platinum-based chemotherapy Microscopic Pathology Small cell variant Resembles small cell carcinomas…
Pancreatoblastoma Laura Webb Lamps, MD Key Facts Clinical Issues Rare overall but most common malignant pancreatic neoplasm of childhood 2/3 of PB occur in children, 1/3 in adults Mean age…
Intraductal Papillary Mucinous Neoplasm Mari Mino-Kenudson, MD Key Facts Terminology Grossly visible, mucin-producing epithelial neoplasm Predominantly grows within main duct &/or its branches Classified into main duct, combined, or branch…
