Multicentric Castleman Disease Pei Lin, MD Key Facts Terminology Systemic lymphoproliferative disease occurs in patients with immunodeficiency or immune dysregulation and is usually associated with human herpesvirus type 8 (HHV8)…
Lipid-associated Lymphadenopathy Tariq Muzzafar, MBBS Key Facts Terminology Lymphadenopathy characterized by accumulation of endogenous or exogenous lipids Etiology/Pathogenesis Endogenous Diabetes mellitus, hyperlipidemia, hepatobiliary diseases Exogenous Total parenteral nutrition Mineral oil…
Unicentric Plasma Cell Variant Castleman Disease Pei Lin, MD Key Facts Terminology Histologically distinctive reaction pattern in lymph node characterized by Marked interfollicular plasmacytosis Regressive (hyaline-vascular) changes in small subset…
Unicentric Hyaline Vascular Variant Castleman Disease Pei Lin, MD Key Facts Clinical Issues Young adults Lymphadenopathy, localized Excision is usually curative Microscopic Pathology Large follicles with regressed (involuted) germinal centers…
Kikuchi-Fujimoto Disease Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Self-limited clinical course in most patients Might represent phenotype of diverse disease entities Prognosis is different according to underlying…
Kimura Disease C. Cameron Yin, MD, PhD Key Facts Terminology Chronic inflammatory disease that affects subcutaneous tissue and regional lymph nodes Etiology/Pathogenesis Unknown; infectious cause suspected Clinical Issues Mainly in…
Sarcoid Lymphadenopathy Sa A. Wang, MD Key Facts Terminology Multisystemic chronic granulomatous disease Etiology/Pathogenesis Unknown Clinical Issues Multisystem involvement Therapy may not be required if asymptomatic Prognosis depends on involvement…
Protocol for Examination of Hodgkin Lymphoma Specimens L. Jeffrey Medeiros, MD Hodgkin Lymphoma: Biopsy, Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Lymph node(s) ____…
Rosai-Dorfman Disease Faisal Alseraye, MD L. Jeffrey Medeiros, MD Key Facts Terminology Rosai-Dorfman disease (RDD) and sinus histiocytosis with massive lymphadenopathy are equivalent terms Etiology/Pathogenesis Unknown; histologic features are suggestive…
Progressive Transformation of Germinal Centers Pei Lin, MD Key Facts Terminology Progressive transformation of germinal centers (PTGC) Clinical Issues Young adults most commonly affected Asymptomatic localized lymphadenopathy in most patients…
