Aneurysmal Bone Cyst
Aneurysmal Bone Cyst Jessica M. Comstock, MD Key Facts Terminology Solitary expansile lesion, most commonly involving long bones or spine Clinical Issues 1st and 2nd decade of life Secondary reactive…
PATHOLOGY & LABORATORY MEDICINE
Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor Karen S. Thompson, MD Key Facts Terminology Tumor of myofibroblastic spindle cells with inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils Intermediate biological potential: Propensity to recur,…
Inclusion Body Fibromatosis
Inclusion Body Fibromatosis Elizabeth A. Montgomery, MD Key Facts Terminology Nodular proliferation of benign fibroblastic and myofibroblastic cells with characteristic intracytoplasmic eosinophilic spherical inclusions Clinical Issues Broad-based or dome-shaped, nontender…
Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva Angelica R. Putnam, MD Key Facts Terminology Rare disabling genetic disorder of progressive heterotopic ossification Etiology/Pathogenesis Heterozygous activating mutation of gene encoding activin receptor A type 1/activin-like…
Malignant Melanoma
Malignant Melanoma Brian J. Hall, MD Key Facts Clinical Issues Knowledge of clinical dimensions is of maximum importance Ensure viewing entirety or most of the lesion before making a benign…
Infectious Mononucleosis Syndromes
Infectious Mononucleosis Syndromes Carla S. Wilson, MD, PhD Key Facts Terminology IM is an acute illness Mainly due to EBV infection ˜ 20% of cases due to CMV or other…
Acute Thymic Involution
Acute Thymic Involution Jessica M. Comstock, MD Key Facts Terminology Incidental thymic involution caused by endogenous steroid release in response to various stressful situations Etiology/Pathogenesis Numerous stressors including infection, chronic…
Transient Erythroblastopenia of Childhood
Transient Erythroblastopenia of Childhood Kathryn Foucar, MD Key Facts Terminology Self-limited red cell aplasia characterized by Normocytic/normochromic anemia with reticulocytopenia Decreased erythroid lineage in bone marrow (red cell aplasia) Etiology/Pathogenesis…
Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis Sa A. Wang, MD Key Facts Terminology Cytokine dysfunction, resulting in activation of T lymphocytes and macrophages Leads to systemic symptoms and organ damage Etiology/Pathogenesis Inherited genetic or…
Mycobacterial Infection
Mycobacterial Infection Tariq Muzzafar, MBBS Key Facts Clinical Issues High index of suspicion essential for diagnosis Definitive diagnosis by histology and culture of LN Molecular methods enable quicker identification of…
