Intrapulmonary Synovial Sarcoma Key Facts Clinical Issues Chest pain Shortness of breath Cough Aggressive behavior with frequent recurrences and metastases Macroscopic Features Well-circumscribed, unencapsulated, solitary mass within lung parenchyma Tan-white…
Adenoid Cystic Carcinoma Key Facts Terminology Epithelial neoplasm similar to that occurring in salivary glands Clinical Issues Presentation Cough, hemoptysis, dyspnea, chest pain Treatment Lobectomy or pneumonectomy Pathogenesis May follow…
Neurogenic Sarcoma (Malignant Peripheral Nerve Sheath Tumor) Key Facts Clinical Issues Extremely rare tumor Often associated with neurofibromatosis Tumors may be central or peripheral Tumors may arise in endobronchial location…
Carcinosarcoma Key Facts Terminology Malignant biphasic neoplasm composed of malignant epithelial and malignant mesenchymal components Etiology/Pathogenesis Carcinosarcomas have been linked to tobacco use Clinical Issues More common in men than…
Pulmonary Blastoma Key Facts Terminology Synonyms: Well-differentiated fetal adenocarcinoma, pulmonary embryoma PB monophasic type (well-differentiated fetal adenocarcinoma): Glandular component recapitulates embryonic development of lung PB biphasic type: Composed of epithelial…
Large Cell (Anaplastic) Carcinoma Key Facts Clinical Issues Cough Chest pain Dyspnea Generally poor prognosis with short survival Most commonly seen in smokers Image Findings Periphery of lungs Generally large…
Pleomorphic Carcinoma Key Facts Terminology Malignant epithelial neoplasm composed of spindle and multinucleated giant cells in different proportions Etiology/Pathogenesis PC may represent a genetically distinct type of malignancy separate from…
Lymphoepithelioma-like Carcinoma Key Facts Terminology Lymphoepithelioma-like carcinoma (LELC) Malignant epithelial neoplasm with prominent inflammatory component Etiology/Pathogenesis Appears not to be related to tobacco smoke Closely associated with Epstein-Barr virus (EBV)…
Poorly Differentiated Squamous Carcinoma, Small Cell Variant Key Facts Clinical Issues Cough History of cigarette smoking Treatment by surgery, chemotherapy, or radiation depends on stage and grade at presentation Image…
Spindle Cell (Sarcomatoid) Carcinoma Key Facts Terminology Carcinoma with pseudosarcomatous component, pseudosarcomatous carcinoma, spindle cell carcinoma Clinical Issues Cough Chest pain Hemoptysis Macroscopic Features Central or peripheral tumors 2 to…
