Diffuse Follicle Center Cell Lymphoma Definition Diffuse follicle center lymphomas (FCL) are diffusely growing, germinal center–derived lymphomas containing predominantly small cleaved B cells or a mix of small cleaved and…
Lymphoplasmacytic Lymphoma Definition At this time, the definition of lymphoplasmacytic lymphoma (LPL) is in flux. In the World Health Organization (WHO) classification, LPL is defined primarily in the context of…
Hairy Cell Leukemia Definition A chronic lymphoproliferative disorder of mature B cells with characteristic cytoplasmic projections. The neoplasm typically infiltrates the bone marrow, spleen, and liver with relatively few hairy…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Definition Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are considered to represent different manifestations of the same disease in the World Health Organization…
Nodal Marginal Zone B-Cell Lymphoma Definition Nodal marginal zone B-cell lymphoma (MZL) is a clinically indolent neoplasm that involves lymph nodes. As defined in the World Health Organization (WHO) classification,…
Lymphoblastic Leukemia/Lymphoma In the World Health Organization (WHO) classification, the commonly used acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are combined into the term lymphoblastic leukemia/lymphoma. This reflects the…
Hodgkin Lymphoma: Classical Definition Hodgkin lymphoma (HL) is characterized by a heterogeneous cellularity comprising a minority of specific neoplastic cells—the Hodgkin cells and the Reed-Sternberg cells—and a majority of reactive…
Hodgkin Lymphoma: Nodular Lymphocyte Predominant Definition A monoclonal B-cell neoplasm characterized by a nodular pattern, with or without diffuse areas, in which large neoplastic lymphocytic and/or histiocytic (L&H) cells are…
Nomenclature and Classification of Lymphomas Traditionally, tumors of various organs have been named and classified according to their histogenesis. This concept is based on the assumption that tumors originate in…
Introduction For the hematopathologist involved in scientific research, lymphomas and leukemias present the most challenging field of medical investigation, one in which immunity and neoplasia interface and in which new…
