Fig. 4.1 Solid-pseudopapillary neoplasm. Pseudopapillary structures with fibrovascular cores (left) and a solid area showing small monomorphic cells (right) Fig. 4.2 Solid-pseudopapillary neoplasm. Cytoplasmic and nuclear β-catenin immunostaining in neoplastic…
Well-differentiated neuroendocrine neoplasm (NEN) NEN G1 NEN G2 Poorly differentiated neuroendocrine carcinoma (NEC) Large-cell NEC Small-cell NEC 8.3 Pathology Macroscopically, PanNENs are usually solitary, solid masses, from 1 to 5…
Fig. 3.1 Mucinous cystedenoma ultrasound. The sonographic scan shows a hypoechoic lesion in the head of the pancreas. The lesions has a macrocystic pattern, as indicated by the large anechoic…
Fig. 11.1 Octreotide amino acid structure. (Reproduced from [2], with permission) The presence of octreotide-binding SSTRs on NENs allows the in vivo functional visualization of these tumors with the use…
Fig. 2.1 Serous cystadenoma: ultrasound (US). Sonographic scans show a hypoechoic lesion with sharp margins in the head of the pancreas (black arrow). Within the lesion, anechoic areas can be…
Fig. 16.1 Metastatic leioomyosarcoma. a Gross appearance of a mesenchymal tumor: the tumor is well circumscribed and composed of soft tissue. b Histologically, the tumor exhibits high cellularity and is…
Author (year) CT (mono-CT) Type Total pts n° n° PanNETs PFS (months) OS (months) RR (%) Brizzi et al. (2009) [42] 5FU (+Octreotide LAR) NEN 29 13 22.6 NR 24.1 …
2. Kulke MH, Anthony LB, Bushnell DL et al (2010) NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas 39:735–752PubMedCrossRef 3. Falconi M, Bartsch DK, Eriksson B…
Type of PanNEN Peptide Site Malignancy (%) MEN1-associated (%) Clinical manifestation Insulinoma Insulin Pancreas 10 10 Hypoglycemia Gastrinoma Gastrin Pancreas, Duodenum 80 25 ZES (peptic ulcer, diarrhea, epigastric pain) VIPoma…
Benign Acinar cell cystadenoma Serous cystadenoma Premalignant lesions Intraductal papillary mucinous neoplasms with low- or intermediate-grade dysplasia Intraductal papillary mucinous neoplasms with high-grade dysplasia Intraductal tubulopapillary neoplasms Mucinous cystic neoplasms…
