The pretherapeutic history of botulinum neurotoxin
Fig. 1.1 Justinus Kerner; photograph of 1855. Kerner again disputed that an inorganic agent such as hydrocyanic acid could be the toxic agent in the sausages, suspecting a biological poison…
GENERAL SURGERY
Pharmacology of botulinum neurotoxins
HSA, human serum albumin; SNAP-25, synaptosomal associated protein-25; VAMP-2, vesicle-associated membrane protein-2. Onset and duration of action Clinical effects of BoNTs develop gradually and are typically evident within a week…
Botulinum neurotoxin: history of clinical development
Chapter 2 Botulinum neurotoxin: history of clinical development Daniel Truong and Mark Hallett Manual of Botulinum Toxin Therapy, 2nd edition, ed. Daniel Truong, Mark Hallett, Christopher Zachary and Dirk Dressler….
interactions
Herb/nutrient-drug interactions NOTES ASSUMPTIONS The following assumptions were made when collating and assessing information for this table: • The clinical significance of many interactions is still unknown because controlled trials…
interactions
Herb–drug interactions INTRODUCTION Complementary medicines such as herbal medicines are available through a variety of channels such as supermarkets, pharmacies, health-food stores, clinic rooms, internet sites and mail order companies….
of herbal medicine
Principles of herbal medicine INTRODUCTION Throughout human history, people have relied on nature to provide their basic needs. Plants in particular have been a source of clothing, shelter, food, flavours…
Regulatory affairs
Chapter 20 Regulatory affairs I. Hägglöf, Å Holmgren Introduction This chapter introduces the reader to the role of the regulatory affairs (RA) department of a pharmaceutical company, outlining the process…
Metabolism and pharmacokinetic optimization strategies in drug discovery
Chapter 10 Metabolism and pharmacokinetic optimization strategies in drug discovery P. Ballard, P. Brassil, K H. Bui, H. Dolgos, C. Petersson, A. Tunek, P J H. Webborn Introduction Optimization of…
Drug discovery and development: facts and figures
Chapter 22 Drug discovery and development facts and figures H P. Rang, R G. Hill In this chapter we present summary information about the costs, timelines and success rates of…
High-throughput screening
Chapter 8 High-throughput screening D. Cronk Introduction: a historical and future perspective Systematic drug research began about 100 years ago, when chemistry had reached a degree of maturity that allowed…
