Engineering Biomaterials for Anchorage-Dependent and Non-anchorage-Dependent Therapeutic Cell Delivery in Translational Medicine
Fig. 4.1 Anoikis activation pathways. Lack of adhesion to the extracellular matrix via integrins (transmembrane proteins consisting of α- and β-subunits) reduces the anti-apoptotic signals Bcl-2 and Bcl-XL. The pro-apoptotic pathways…