Lymphadenopathies of Salivary Glands Definition Lymphadenitides and lymphadenopathies of salivary glands, lymphoid characterized by lymphoepithelial lesions (LEL). Pathogenesis Normally, lymphoid tissues are intimately associated with salivary glands in various forms…
Dermatopathic Lymphadenopathy Definition Reactive paracortical hyperplasia of lymph node characterized by an increased number of interdigitating dendritic cells, Langerhans cells, and histiocytes with cytoplasmic melanin deposits and lipid vacuoles. These…
Rheumatoid Lymphadenopathy Definition Lymphadenopathy accompanying rheumatoid arthritis (RA). Epidemiology Rheumatoid arthritis is common disease, affecting 0.8% of the world’s population (1). Approximately 2 million people in the United States have…
Sarcoidosis Lymphadenopathy Definition Sarcoidosis is a multisystem granulomatous disease of worldwide distribution and unknown cause. Epidemiology Sarcoidosis occurs worldwide, affecting persons of all races and ages. A seasonal clustering prevails,…
Systemic Lupus Lymphadenopathy Definition Lymphadenopathy associated with systemic lupus erythematosus (SLE). Synonym Lupus lymphadenopathy; lupus lymphadenitis. Epidemiology Systemic lupus erythematosus has a worldwide distribution, with differences in prevalence related to…
Kikuchi Lymphadenopathy Synonyms Kikuchi disease; Kikuchi Fujimoto lymphadenopathy; Histiocytic necrotizing lymphadenitis. Definition Subacute necrotizing regional lymphadenopathy associated with mild fever, more common in young Asian people. Epidemiology Described independently in…
Sinus Histiocytosis with Massive Lymphadenopathy Definition A rare benign disorder of histiocytes characterized histologically by intracellular engulfment of lymphocytes. Synonyms Rosai-Dorfman disease; Histiocytose lipidique ganglionnaire pseudotumorale de Destombes; lymphadenitis with…
Kimura Lymphadenopathy Definition Kimura disease is a chronic inflammatory disorder prevalent in Asians. It involves subcutaneous tissues and lymph nodes predominantly in the head and neck region and is characterized…
Progressive Transformation of Germinal Centers Definition Progressive transformation of germinal centers (PTGC) is a benign reaction pattern in lymph nodes. The lesion of PTGC is composed of large nodules in…
Atypical Lymphoid Hyperplasia Definition Hyperplasia with atypical histologic or cytologic features of lymph nodes (or of other lymphoid organs), suggestive but not diagnostic of lymphoma. Pathogenesis Atypical lymphoid hyperplasia (ALH)…
