Human Genetic Disorders
Fig. 13.1. Down syndrome – brushfield spots on irides (A). Single transverse palmar creases and fifth finger clinodactyly (B). Gap between first and second toe (C). ♦ Developmental delay,…
Molecular Pathology of Solid Tumors
Tumor Cytogenetic alteration Fusion genes [significance] Alveolar rhabdomyosarcoma t(2;13)(q35;q14) PAX3–FOXO1(FKHR) Alveolar rhabdomyosarcoma t(1;13)(p36;q14) PAX7–FOXO1(FKHR) – [favorable prognosis] Alveolar soft part sarcoma t(X;17)(p11;q25) TFE3–ASPSCR1(ASPL) – [sensitive to MET inhibitors] Clear cell…
Biomedical Informatics for Anatomic Pathology
Fig. 9.1. Barcode scanning at gross station equipped with barcoding scanners for material tracking. Historical Perspective 1960–2000 ♦ Interdisciplinary field at the cross section of biology, medicine, computer science,…
Quality Assurance and Regulations for Anatomic Pathology
Fig. 10.1. The “no blame box”. Specimens can be charted into one of the four categories of cancer/no cancer and good quality/poor quality. This method often illustrates that errors are…
Malignant Glandular Lesions of the Cervix
(1) Department of Pathology, Royal Victoria Hospital, Belfast, UK Abstract Cervical adenocarcinomas are increasing in incidence and now account for approximately 25 % of cervical carcinomas in most developed…
Benign Endocervical Glandular Lesions
(1) Department of Pathology, Royal Victoria Hospital, Grosvenor Road, Belfast, UK Abstract This chapter covers the many benign endocervical glandular lesions, some of which may mimic premalignant and malignant…
Cytology of Glandular Lesions
(1) Department of Histopathology and Cytology, Royal Hallamshire Hospital, Sheffield, UK Abstract In this chapter the appearance of in situ and invasive glandular neoplasms of the cervix and their…
Other Neoplasms of the Cervix
(1) Department of Pathology, Royal Victoria Hospital, Belfast, UK Abstract This chapter deals with uncommon primary cervical neoplasms. Tumours covered in this chapter include neuroendocrine neoplasms of which the…
Premalignant Glandular Lesions of the Cervix
(1) Department of Pathology, Royal Victoria Hospital, Belfast, UK Abstract Premalignant endocervical glandular lesions are increasing in incidence. The various terminologies applied to these lesions (adenocarcinoma in situ or…
